Synthesis and biological evaluation of new benzo[f]furo[2,3-h]- and benzo[f]pyrano[2,3-h]coumarin derivatives.

被引：4
|
作者：
Tsoukka, Maria
Litinas, Konstantinos E. [1 ]
Nicolaides, Demetrios N.
Hadjipavlou-Litina, Dimitra J.
机构：
[1] Aristotle Univ Thessaloniki, Dept Chem, Organ Chem Lab, Thessaloniki 54124, Greece
[2] Aristotle Univ Thessaloniki, Sch Pharm, Dept Pharmaceut Chem, Thessaloniki 54124, Greece
来源：
JOURNAL OF HETEROCYCLIC CHEMISTRY | 2007年 / 44卷 / 03期
关键词：
COUMARIN DERIVATIVES; MEDICINAL CHEMISTRY; ORTHO-QUINONES; ANALOGS; ANTIOXIDANTS; AGENTS;
D O I：
10.1002/jhet.5570440304
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Furocoumarins 3, 5 and pyranocoumarin 7 were synthesized from-the reaction of furonaphthalenediones 2, 4 and pyranonaphthalenedione 6 respectively with carbethoxymethylene(triphenyl)phosphorane in refluxing DCM for 3-6 hours or under microwave irradiation in toluene for a few minutes. Compounds 3, 5, 7 and their precursors were tested as anti-inflammatory/antioxidant agents. They were found to compete significantly high-DMSO for OH radicals, to scavenge O-2(-) and to inhibit lipoxygenase to a high extent.
引用
收藏
页码：529 / 534
页数：6
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