Peroxisome proliferator-activated receptors gamma ligands and ischemia and reperfusion injury

被引：42
|
作者：
Cuzzocrea, S [1 ]
机构：
[1] Univ Messina, Sch Med, Dept Chem & Expt Med & Pharmacol, Policlin Univ, I-98123 Messina, Italy
来源：
VASCULAR PHARMACOLOGY | 2004年 / 41卷 / 06期
关键词：
PPAR-gamma; ischemia; reperfusion;
D O I：
10.1016/j.vph.2004.10.004
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Peroxisome proliferator-activated receptors (PPARs) are members of the nuclear hormone receptor superfamily of ligand-activated transcription factors that are related to retinoid, steroid and thyroid hormone receptors. The PPAR subfamily comprises of three members, PPAR-alpha., PPAR-beta and PPAR-gamma. PPAR-gamma has recently been implicated as a regulator of cellular proliferation and inflammatory responses. There is good evidence that ligands of PPAR-gamma, including certain thiazolinediones. reduce tissue injury associated with ischemia and reperfusion. The potential utility of PPAR-gamma ligands in ischemia and reperfusion will be discussed in this review. (C) 2004 Elsevier Inc. All rigths reserved.
引用
收藏
页码：187 / 195
页数：9
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