Reductions in blood pressure during a community-based overweight and obesity treatment in children and adolescents with prehypertension and hypertension

被引:9
|
作者
Mollerup, P. M. [1 ]
Lausten-Thomsen, U. [1 ]
Fonvig, C. E. [1 ,2 ]
Baker, J. L. [2 ,3 ,4 ]
Holm, J-C [1 ,2 ,5 ]
机构
[1] Copenhagen Univ Hosp Holbaek, Dept Pediat, Childrens Obes Clin, Smedelundsgade 60, DK-4300 Holbaek, Denmark
[2] Univ Copenhagen, Sect Metab Genet, Ctr Basic Metab Res, Sect Metab Genet,Novo Nordisk Fdn, Copenhagen, Denmark
[3] Capital Reg, Bispebjerg Hosp, Inst Prevent Med, Frederiksberg, Denmark
[4] Capital Reg, Frederiksberg Hosp, Inst Prevent Med, Frederiksberg, Denmark
[5] Univ Copenhagen, Fac Hlth & Med Sci, Copenhagen, Denmark
关键词
RANDOMIZED CONTROLLED-TRIAL; TASK-FORCE COTF; CHILDHOOD OBESITY; EUROPEAN ASSOCIATION; PUBERTAL CHANGES; OUTCOMES; ATHEROSCLEROSIS; RECOMMENDATIONS; INTERVENTION; PREVALENCE;
D O I
10.1038/jhh.2017.36
中图分类号
R6 [外科学];
学科分类号
1002 ; 100210 ;
摘要
Due to the pandemic of childhood obesity and thus obesity-related hypertension, improvements in treatment availability are needed. Hence, we investigated whether reductions in blood pressure (BP) would occur in children with overweight and obesity exhibiting prehypertension/hypertension during a community-based overweight and obesity treatment program, and if changes in body mass index (BMI) are associated with changes in BP. The study included 663 children aged 3-18 years with a BMI. 85th percentile for sex and age that entered treatment from June 2012 to January 2015. Height, weight and BP were measured upon entry and every 3-6 months. BMI and BP s.d. scores (SDSs) were calculated according to sex and age, or sex, age and height. Prehypertension was defined as a BP SDS. 1.28 and o1.65. Hypertension was defined as a BP SDS. 1.65. Upon entry, 52% exhibited prehypertension (11.9%) or exhibited hypertension (40.1%). After 12 months (range: 3-29) of treatment, 29.3% of the children with prehypertension/hypertension were normotensive. Children with systolic prehypertension/hypertension upon entry reduced their systolic BP SDSs by 0.31 (95% confidence interval (CI): 0.70-0.83, P < 0.0001). Children with diastolic prehypertension/ hypertension upon entry reduced their diastolic BP SDSs by 0.78 (95% CI: 0.78-0.86, P < 0.0001). BMI SDS changes were positively associated with BP SDS changes (P < 0.0001). Nonetheless, some children reduced BP SDSs while increasing their BMI SDSs, and prehypertension/hypertension developed in 23.3% of the normotensive children despite reductions in BMI SDSs (P < 0.0001). These results suggest that community-based overweight and obesity treatment can reduce BP, and thus may help improve treatment availability.
引用
收藏
页码:640 / 646
页数:7
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