Tumor-infiltrating CD8+ T cell antitumor efficacy and exhaustion: molecular insights

被引：39
|
作者：
Kumar, Sandeep [1 ]
Singh, Sunil Kumar [1 ]
Rana, Basabi [1 ,2 ,3 ]
Rana, Ajay [1 ,2 ,3 ]
机构：
[1] Univ Illinois, Div Surg Oncol, Dept Surg, Chicago, IL 60612 USA
[2] Univ Illinois, Univ Illinois Hosp & Hlth Sci Syst Canc Ctr, Chicago, IL 60612 USA
[3] Jesse Brown VA Med Ctr, Chicago, IL 60612 USA
来源：
DRUG DISCOVERY TODAY | 2021年 / 26卷 / 04期
关键词：
INTRATUMORAL IMMUNOTHERAPY; LYMPHOCYTE THERAPY; PHOSPHORYLATED ERK; PD-1; BLOCKADE; LUNG-CANCER; CHECKPOINT; MELANOMA; IMMUNITY; ANTIGEN; AGONIST;
D O I：
10.1016/j.drudis.2021.01.002
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Host immunity has an essential role in the clinical management of cancers. Therefore, it is advantageous to choose therapies that can promote tumor cell death and concurrently boost host immunity. The dynamic tumor microenvironment (TME) determines whether an antineoplastic drug will elicit favorable or disparaging immune responses from tumor-infiltrating lymphocytes (TILs). CD8+ T cells are one of the primary tumor-infiltrating immune cells that deliver antitumor responses. Here, we review the influence of various factors in the TME on CD8+ T cell exhaustion and survival, and possible strategies for restoring CD8+ T cell effector function through immunotherapy.
引用
收藏
页码：951 / 967
页数：17
相关论文
共 50 条
  • [21] Intraepithelial CD8+ tumor-infiltrating lymphocytes and a high CD8+/regulatory T cell ratio are associated with favorable prognosis in ovarian cancer
    Sato, E
    Olson, SH
    Ahn, J
    Bundy, B
    Nishikawa, H
    Qian, F
    Jungbluth, AA
    Frosina, D
    Gnjatic, S
    Ambrosone, C
    Kepner, J
    Odunsi, T
    Ritter, G
    Lele, S
    Chen, YT
    Ohtani, H
    Old, LJ
    Odunsi, K
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (51) : 18538 - 18543
  • [22] Expansion of Tumor-Infiltrating CD8+ T cells Expressing PD-1 Improves the Efficacy of Adoptive T-cell Therapy
    Fernandez-Poma, Sarita M.
    Salas-Benito, Diego
    Lozano, Teresa
    Casares, Noelia
    Riezu-Boj, Jose-Ignacio
    Mancheno, Uxua
    Elizalde, Edurne
    Alignani, Diego
    Zubeldia, Natalia
    Otano, Itziar
    Conde, Enrique
    Sarobe, Pablo
    Jose Lasarte, Juan
    Hervas-Stubbs, Sandra
    CANCER RESEARCH, 2017, 77 (13) : 3672 - 3684
  • [23] Cholesterol Induces CD8+ T Cell Exhaustion in the Tumor Microenvironment
    Ma, Xingzhe
    Bi, Enguang
    Lu, Yong
    Su, Pan
    Huang, Chunjian
    Liu, Lintao
    Wang, Qiang
    Yang, Maojie
    Kalady, Matthew F.
    Qian, Jianfei
    Zhang, Aijun
    Gupte, Anisha A.
    Hamilton, Dale J.
    Zheng, Chengyun
    Yi, Qing
    CELL METABOLISM, 2019, 30 (01) : 143 - +
  • [24] CD8+ T Cell Exhaustion in Cancer
    Dolina, Joseph S.
    Van Braeckel-Budimir, Natalija
    Thomas, Graham D.
    Salek-Ardakani, Shahram
    FRONTIERS IN IMMUNOLOGY, 2021, 12
  • [25] Tumor-infiltrating CD8+ T-cell density is an independent prognostic marker for oral squamous cell carcinoma
    Shimizu, Shota
    Hiratsuka, Hiroyoshi
    Koike, Kazushige
    Tsuchihashi, Kei
    Sonoda, Tomoko
    Ogi, Kazuhiro
    Miyakawa, Akira
    Kobayashi, Junichi
    Kaneko, Takeshi
    Igarashi, Tontohiro
    Hasegawa, Tadashi
    Miyazaki, Akihiro
    CANCER MEDICINE, 2019, 8 (01): : 80 - 93
  • [26] IL-7-primed bystander CD8 tumor-infiltrating lymphocytes optimize the antitumor efficacy of T cell engager immunotherapy
    Lee, Kun-Joo
    Choi, Donghoon
    Tae, Nara
    Song, Ha Won
    Kang, Yeon-Woo
    Lee, Minji
    Moon, Dain
    Oh, Youngsik
    Park, Sujeong
    Kim, Ji-Hae
    Jeong, Siheon
    Yang, Jaehyuk
    Park, Uni
    Hong, Da Hee
    Byun, Mi-Sun
    Park, Su-Hyung
    Sohn, Joohyuk
    Park, Yunji
    Im, Sun-Kyoung
    Choi, Sun Shim
    Kim, Dae Hee
    Lee, Seung-Woo
    CELL REPORTS MEDICINE, 2024, 5 (05)
  • [27] NKG2A checkpoint receptor expression on tumor-infiltrating CD8+ T cells restrains efficacy of immunotherapy
    van Hall, Thorbald
    van Montfoort, Nadine
    Piersma, Sytse
    Sluijter, Marjolein
    Welters, Marij J.
    Andre, Pascale
    Wagtmann, Nicolai
    van der Burg, Sjoerd H.
    CANCER RESEARCH, 2017, 77
  • [28] Genetically driven CD39 expression shapes human tumor-infiltrating CD8+ T-cell functions
    Gallerano, Daniela
    Ciminati, Selina
    Grimaldi, Alessio
    Piconese, Silvia
    Cammarata, Ilenia
    Focaccetti, Chiara
    Pacella, Ilenia
    Accapezzato, Daniele
    Lancellotti, Francesco
    Sacco, Luca
    Caronna, Roberto
    Melaiu, Ombretta
    Fruci, Doriana
    D'Oria, Valentina
    Manzi, Emy
    Sagnotta, Andrea
    Parrino, Chiara
    Coletta, Diego
    Peruzzi, Giovanna
    Terenzi, Valentina
    Battisti, Andrea
    Cassoni, Andrea
    Fadda, Maria Teresa
    Brozzetti, Stefania
    Fazzi, Katia
    Grazi, Gian Luca
    Valentini, Valentino
    Chirletti, Piero
    Polimeni, Antonella
    Barnaba, Vincenzo
    Timperi, Eleonora
    INTERNATIONAL JOURNAL OF CANCER, 2020, 147 (09) : 2597 - 2610
  • [29] An integrative analysis of the single-cell transcriptome identifies DUSP4 as an exhaustion-associated gene in tumor-infiltrating CD8+ T cells
    Yu Zhao
    Huihui Cai
    Xiaoling Ding
    Xiaorong Zhou
    Functional & Integrative Genomics, 2023, 23
  • [30] Transcriptome of CD8+ tumor-infiltrating T cells: a link between diabetes and colorectal cancer
    Saleh, Reem
    Nair, Varun Sasidharan
    Murshed, Khaled
    Abu Nada, Mohamed
    Elkord, Eyad
    Shaheen, Ranad
    CANCER IMMUNOLOGY IMMUNOTHERAPY, 2021, 70 (09) : 2625 - 2638
12345