Show Me the Money! Process Modeling in Pharma from the Investor's Point of View

被引:5
|
作者
Varsakelis, Christos [1 ]
Dessoy, Sandrine [1 ]
von Stosch, Moritz [1 ]
Pysik, Alexander [1 ]
机构
[1] GSK Biol, Tech Res & Dev, B-1330 Rixensart, Belgium
关键词
process modeling; return on investment; diffusion of innovation; MECHANISTIC MODELS; TECHNOLOGY;
D O I
10.3390/pr7090596
中图分类号
TQ [化学工业];
学科分类号
0817 ;
摘要
Process modeling in pharma is gradually gaining momentum in process development but budget restrictions are growing. We first examine whether and how current practices rationalize within a decision process framework with a fictitious investor facing a decision problem subject to incomplete information. We then develop an algorithmic procedure for investment evaluation on both monetary and diffusion-of-innovation fronts. Our methodology builds upon discounted cash flow analysis and Bayesian inference and utilizes the Rogers diffusion of innovation paradigm for computing lower expected returns. We also introduce a set of intangible metrics for quantifying the level of diffusion of process modeling within an organization.
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页数:13
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