The delta opioid receptor: a novel therapeutic target for pain and even more ...

被引：0
|
作者：
Gaveriaux-Ruff, C. [1 ]
机构：
[1] Univ Strasbourg, Dept Neurobiol & Genet, INSERM, IGBMC,CNRS,UMR7104,U964, F-67400 Illkirch Graffenstaden, France
来源：
DOULEUR ET ANALGESIE | 2009年 / 22卷 / 04期
关键词：
Opioid receptor; Delta; Chronic pain; Anxiety depression; ANTIDEPRESSANT-LIKE ACTIVITIES; PROTEIN-COUPLED RECEPTORS; RAT MODEL; AGONIST SNC80; NEUROPATHIC PAIN; FUNCTIONAL COMPETENCE; ANTINOCICEPTIVE PROPERTIES; CHRONIC INFLAMMATION; MORPHINE-TOLERANCE; RHESUS-MONKEYS;
D O I：
10.1007/s11724-009-0146-3
中图分类号：
R614 [麻醉学];
学科分类号：
100217 ;
摘要：
The delta opioid receptor is a novel target for pain treatment. The delta receptor appears different from the mu receptor as it is poorly effective for acute nociception but becomes more active in pathological situations. The interest for this receptor has increased recently with the identification of novel ligands and the study of its intracellular traffic. In addition, delta receptor activation lowers anxiety and depression. This review presents the recent knowledge on delta opioid analgesia and on the other neurobiological effects of delta receptor activation.
引用
收藏
页码：201 / 209
页数：9
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