Neutrophil elastase in cervical fluid in women with short cervical length

被引:7
|
作者
Choi, Soo Ran [1 ]
Hong, Soon-Sun [2 ]
Kim, Juyoung [2 ]
Lee, Keun-Young [3 ]
机构
[1] Inha Univ, Coll Med, Dept Obstet & Gynecol, Incheon, South Korea
[2] Inha Univ, Coll Med, Dept New Drug Dev, Incheon, South Korea
[3] Hallym Univ, Coll Med, Kangnam Sacred Heart Hosp, Dept Obstet & Gynecol, 948-1 Daelim 1 Dong, Seoul 150950, South Korea
来源
TAIWANESE JOURNAL OF OBSTETRICS & GYNECOLOGY | 2018年 / 57卷 / 03期
关键词
Neutrophil elastase; Preterm birth; Secretory leukocyte protease inhibitor; Short cervix; LEUKOCYTE PROTEASE INHIBITOR; GRANULOCYTE ELASTASE; PRETERM DELIVERY; UTERINE CERVIX; INTERLEUKIN-8; MUCUS; MANAGEMENT; CYTOKINES; SECRETION; RISK;
D O I
10.1016/j.tjog.2018.04.014
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Objective: The aim of the study was to determine the relationships between short cervical length (CL) and levels of cervical fluid neutrophil elastase (NE), secretory leukocyte protease inhibitor (SLPI), and interleukin 8 (IL-8) in the second trimester of pregnancy of women who underwent ultrasound-indicated cervical cerclage. Materials and methods: CL of < 25 mm or cervical funneling were included in the short CL group (n = 26) and the normal CL group (n = 22) included women who had CL of >= 25 mm and had no cervical funneling in women between 17 thorn 0 and 24 thorn 6 weeks of gestation. Levels of NE, SLPI, and IL-8 were measured by using enzyme-linked immunosorbent assay kits. ManneWhitney U tests and Spearman's correlation analysis were used for statistical analyses. Results: Compared with the normal CL group, the short CL group had significantly higher median NE levels (P < 0.001) and higher, though not significant, median IL-8 levels by approximately three times (2107.0 vs. 798.3 pg/mL, P = 0.132). The median SLPI levels in cervical fluid was similar between the two groups (107.6 vs. 103.2 ng/mL, P = 0.499). Short CL had a significant correlations with cervical fluid NE levels (r = -0.475, P = 0.001). Conclusion: Increased cervical fluid NE associated with cervical shortening in second trimester of pregnancy, whereas cervical fluid SLPI had constant levels. (C) 2018 Taiwan Association of Obstetrics & Gynecology. Publishing services by Elsevier B.V.
引用
收藏
页码:407 / 410
页数:4
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