Stem cell factor, the JAK-STAT pathway and signal transduction

被引：41
|
作者：
Linnekin, D [1 ]
Mou, S [1 ]
Deberry, CS [1 ]
Weiler, SR [1 ]
Keller, JR [1 ]
Ruscetti, FW [1 ]
Longo, DL [1 ]
机构：
[1] NCI, Lab Leukocyte Biol, Div Basic Sci, Frederick Canc Res & Dev Ctr, Frederick, MD 21701 USA
来源：
LEUKEMIA & LYMPHOMA | 1997年 / 27卷 / 5-6期
关键词：
cytokines; growth factors; signal transduction; hematopoiesis;
D O I：
10.3109/10428199709058310
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Recent work has demonstrated the importance of Janus family kinases (JAKs) and signal transducers and activators of transcription (STATs) in the stimulus-response coupling of receptors lacking intrinsic tyrosine kinase activity. In particular, the JAK-STAT pathway appears critical in signal transduction by interferon as well as numerous hematopoietic growth factors interacting with members of the hemapoietin receptor superfamily. Although ligands that interact with receptor tyrosine kinases (RTK), such as epidermal growth factor (EGF), platelet-derived growth factor (PDGF) and colony stimulating factor-1 (CSF-1), have been shown to induce increases in phosphorylation of both JAKs and STATs, little is known about activation of this pathway by stem cell factor (SCF). This review will summarize what is known about the JAK/STAT pathway in relation to SCF signal transduction.
引用
收藏
页码：439 / 444
页数：6
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