Therapeutic Response of Soft Tissue Sarcoma With Novel SS18-POU5F1 Fusion: A Case Report

被引：3
|
作者：
Liu, Zengjun [1 ,2 ,3 ]
Yuan, Hongtu [3 ,4 ]
Han, Mingyong [1 ]
机构：
[1] Shandong Univ, Shandong Prov Hosp, Cheeloo Coll Med, Tumor Res & Therapy Ctr, Jinan, Peoples R China
[2] Shandong First Med Univ, Rare Tumors Dept, Shandong Canc Hosp & Inst, Jinan, Peoples R China
[3] Shandong Acad Med Sci, Jinan, Peoples R China
[4] Shandong First Med Univ, Dept Pathol, Shandong Canc Hosp & Inst, Jinan, Peoples R China
来源：
FRONTIERS IN ONCOLOGY | 2021年 / 11卷
关键词：
soft tissue sarcoma; SS18; fusion; therapeutic response;
D O I：
10.3389/fonc.2021.666946
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
A novel SS18-POU5F1 fusion gene was recently reported in soft tissue sarcoma occurring in three adolescent and young adult patients. Herein, we firstly reported the treatment response of SS18-POU5F1 sarcoma to immune checkpoint inhibitor, angiogenesis inhibitor, chemotherapy and radiotherapy. Our patient demonstrated no response to various systemic therapies including immune checkpoint inhibitor, angiogenesis inhibitor and chemotherapy. However, we noted that the SS18-POU5F1 sarcoma had a quick, robust but transient clinical response to radiotherapy. Further studies are needed to elucidate the mechanism underlying the different tumor response to radiotherapy and systemic therapy in this kind of tumor.
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页数：3
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