attenuation;
environmental epidemiology;
geostatistics;
measurement error;
mixed models;
random effects;
SEIFA;
sensitivity;
spatial correlation;
spatial linear regression;
LINEAR MIXED MODELS;
INFERENCE;
EXPOSURE;
CANCER;
BIAS;
D O I:
10.1002/env.2305
中图分类号:
X [环境科学、安全科学];
学科分类号:
08 ;
0830 ;
摘要:
Spatial regression models have grown in popularity in response to rapid advances in geographic information system technology that allows epidemiologists to incorporate geographically indexed data into their studies. However, it turns out that there are some subtle pitfalls in the use of these models. We show that the presence of covariate measurement error can lead to significant sensitivity of parameter estimation to the choice of spatial correlation structure. We quantify the effect of measurement error on parameter estimates and then suggest two different ways to produce consistent estimates. We evaluate the methods through a simulation study. These methods are then applied to data on ischaemic heart disease. Copyright (c) 2014 John Wiley & Sons, Ltd.
机构:
Eli Lilly & Co, Lilly Corp Ctr, Exploratory Program Med Stat, Indianapolis, IN 46285 USAEli Lilly & Co, Lilly Corp Ctr, Exploratory Program Med Stat, Indianapolis, IN 46285 USA
McGlothlin, Anna
Stamey, James D.
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h-index: 0
机构:
Baylor Univ, Dept Stat Sci, Waco, TX 76798 USAEli Lilly & Co, Lilly Corp Ctr, Exploratory Program Med Stat, Indianapolis, IN 46285 USA
Stamey, James D.
Seaman, John W., Jr.
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机构:
Baylor Univ, Dept Stat Sci, Waco, TX 76798 USAEli Lilly & Co, Lilly Corp Ctr, Exploratory Program Med Stat, Indianapolis, IN 46285 USA
机构:
Shanghai Normal Univ, Math & Sci Coll, Shanghai, Peoples R China
Chinese Univ Hong Kong, Dept Stat, Hong Kong, Hong Kong, Peoples R ChinaShanghai Normal Univ, Math & Sci Coll, Shanghai, Peoples R China
Wu, Yueqin
Gu, Minggao
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机构:
Chinese Univ Hong Kong, Dept Stat, Hong Kong, Hong Kong, Peoples R ChinaShanghai Normal Univ, Math & Sci Coll, Shanghai, Peoples R China