Visible-Light-Induced Alkylarylation of Unactivated Alkenes via Radical Addition/Truce-Smiles Rearrangement Cascade

被引：17
|
作者：
He, Chonglong [1 ,2 ]
Zhang, Keyuan [1 ,2 ]
Wang, Dan-Ning [1 ,2 ]
Wang, Min [1 ,2 ]
Niu, Yuejie [1 ,2 ]
Duan, Xin-Hua [1 ,2 ]
Liu, Le [1 ,2 ]
机构：
[1] Xi An Jiao Tong Univ, Sch Chem, Xian Key Lab Sustainable Energy Mat Chem, Xian 710049, Peoples R China
[2] Xi An Jiao Tong Univ, MOE Key Lab Nonequilibrium Synth & Modulat Conden, Xian 710049, Peoples R China
来源：
ORGANIC LETTERS | 2022年 / 24卷 / 14期
基金：
中国国家自然科学基金;
关键词：
MIGRATION STRATEGY; CYANO MIGRATION; FUNCTIONALIZATION; DIFUNCTIONALIZATION;
D O I：
10.1021/acs.orglett.2c00875
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
We disclosed a visible-light-induced alkylarylation reaction of unactivated alkenes via a metal-free radical addition/aryl translocation cascade sequence. Distal olefinic sulfonate was designed as a unique molecular scaffold allowing for a dominoprocess to synthesize valuable alkylarylated alcohols in good yields with excellent diastereoselectivity, featuring mild reactionconditions, broad substrate scope, and excellent functional group tolerance. The mechanism investigation suggests that a visible-light-induced radical chain process dominates the cascade transformation.
引用
收藏
页码：2767 / 2771
页数：5
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