Reduced blood pressure responsiveness to skeletal muscle metaboreflex activation in older adults following inorganic nitrate supplementation

被引:21
|
作者
Schneider, Aaron C. [1 ]
Hughes, William E. [1 ]
Ueda, Kenichi [4 ]
Bock, Joshua M. [1 ]
Casey, Darren P. [1 ,2 ,3 ]
机构
[1] Dept Phys Therapy & Rehabil Sci, Iowa City, IA USA
[2] Abboud Cardiovasc Res Ctr, Iowa City, IA USA
[3] Fraternal Order Eagles Diabet Res Ctr, Iowa City, IA USA
[4] Univ Iowa, Dept Anesthesia, Carver Coll Med, Iowa City, IA 52242 USA
来源
NITRIC OXIDE-BIOLOGY AND CHEMISTRY | 2018年 / 78卷
关键词
Aging; Blood pressure responsiveness; Metaboreflex; Nitric oxide; Inorganic nitrate; DIETARY NITRATE; NITRIC-OXIDE; HEMODYNAMIC-RESPONSE; INDUCED HYPERTENSION; ISOMETRIC-EXERCISE; HYPOXIC EXERCISE; OXIDATIVE STRESS; DYNAMIC EXERCISE; BEETROOT JUICE; HEART-RATE;
D O I
10.1016/j.niox.2018.05.010
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The vasoactive molecule nitric oxide (NO) contributes to regulation of blood pressure (BP) at rest and during exercise. Age-related exaggerated increased BP responses during exercise have been proposed to be due in part to a decreased NO bioavailability and possibly an enhanced skeletal muscle metaboreflex. In the present study we sought to determine if age-related differences in BP responses to skeletal muscle metaboreflex activation exist. Additionally, since NO bioavailability can be improved with exogenous nitrate (NO3-) via the nitrate-nitrite-NO pathway, we tested the hypothesis that inorganic NO3- supplementation would reduce BP responses to muscle metaboreflex activation in healthy older adults. 13 older adults (67 1 years) participated in a randomized, double-blind, placebo controlled crossover study consisting of four weeks of NO3- supplementation [beetroot powder; 250 mg (similar to 4.03 mmol) of NO3- and 20 mg (similar to 0.29 mmol) of NO2-] and four weeks of placebo (beetroot powder devoid of NO3- /NO2-). Skeletal muscle metaboreflex testing consisted of isometric handgrip exercise (IHG) at 30% of maximal voluntary contraction immediately followed by post exercise forearm ischemia (PEI), which was achieved by inflation of a rapid pressure cuff (240 mmHg) around the upper arm. BP responses were analyzed as the change (Delta) from baseline to the end of IHG and PEI. An additional 10 young adults (25 1 years) were recruited to serve as a reference cohort and address if BP responses to skeletal muscle metaboreflex activation were greater with aging. BP responses to IHG were similar between the young and older adults. However, older adults demonstrated a greater increase in systolic BP during PEI (P < 0.05). Plasma NO3- and NO2- were increased following NO3- supplementation in older adults (P < 0.01). Delta Systolic BP (19 +/- 2 vs. 13 +/- 3 mmHg, P < 0.05), Delta Diastolic BP (7 +/- 1 vs. 5 +/- 1 mmHg, P < 0.05) and Delta Mean arterial pressure (11 +/- 1 vs. 8 +/- 2 mmHg, P < 0.05) were reduced during PEI following four weeks of NO3- supplementation, whereas placebo had no effect on ASystolic BP (16 +/- 2 vs. 17 +/- 2 mmHg), Delta Diastolic BP (5 +/- 1 vs. 7 +/- 1 mmHg), and Delta Mean arterial pressure (8 +/- 1 vs. 10 +/- 1 mmHg) during PEI (all P > 0.05). These data suggest that inorganic NO3- supplementation attenuates skeletal muscle metaboreflex mediated increases in BP during exercise in older adults.
引用
收藏
页码:81 / 88
页数:8
相关论文
共 50 条
  • [21] Inorganic nitrate and nitrite supplementation fails to improve skeletal muscle mitochondria efficiency in mice and humans
    Ntessalen, Maria
    Procter, Nathan E. K.
    Schwarz, Konstantin
    Loudon, Brodie L.
    Minnion, Magdalena
    Fernandez, Bernadette O.
    Vassiliou, Vassilios S.
    Vauzour, David
    Madhani, Melanie
    Constantin-Teodosiu, Dumitru
    Horowitz, John D.
    Feelisch, Martin
    Dawson, Dana
    Crichton, Paul G.
    Frenneaux, Michael P.
    AMERICAN JOURNAL OF CLINICAL NUTRITION, 2020, 111 (01): : 79 - 89
  • [22] Increased Systolic Blood Pressure Driven Skeletal Muscle Activation Following Stroke: A Causality Study
    Verma, Ajay K.
    Xu, Da
    Goswami, Nandu
    Garg, Amanmeet
    Fazekas, Franz
    Roessler, Andreas
    Blaber, Andrew
    Fazel-Rezai, Reza
    Tavakolian, Kouhyar
    2016 COMPUTING IN CARDIOLOGY CONFERENCE (CINC), VOL 43, 2016, 43 : 29 - 32
  • [23] Effects of short-term dietary nitrate supplementation on blood pressure, O2 uptake kinetics, and muscle and cognitive function in older adults
    Kelly, James
    Fulford, Jonathan
    Vanhatalo, Anni
    Blackwell, Jamie R.
    French, Olivia
    Bailey, Stephen J.
    Gilchrist, Mark
    Winyard, Paul G.
    Jones, Andrew M.
    AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 2013, 304 (02) : R73 - R83
  • [24] Does Strength Influence Blood Pressure Responses To Muscle Metaboreflex Activation In Men Living With HIV?
    Borges, Juliana P.
    Gama, Gabriel
    Rangel, Marcus V. D. S.
    Lopes, Karynne G.
    MEDICINE & SCIENCE IN SPORTS & EXERCISE, 2022, 54 (09) : 379 - 379
  • [25] Maintenance of skeletal muscle function following reduced daily physical activity in healthy older adults: a pilot trial
    Oikawa, Sara Y.
    Callahan, Damien M.
    McGlory, Chris
    Toth, Michael J.
    Phillips, Stuart M.
    APPLIED PHYSIOLOGY NUTRITION AND METABOLISM, 2019, 44 (10) : 1052 - 1056
  • [26] Influence of iodide ingestion on nitrate metabolism and blood pressure following short-term dietary nitrate supplementation in healthy normotensive adults
    Bailey, Stephen J.
    Blackwell, Jamie R.
    Wylie, Lee J.
    Emery, Annabelle
    Taylor, Ellie
    Winyard, Paul G.
    Jones, Andrew M.
    NITRIC OXIDE-BIOLOGY AND CHEMISTRY, 2017, 63 : 13 - 20
  • [27] Inorganic Nitrate Supplementation Lowers Blood Pressure in Humans Role for Nitrite-Derived NO
    Kapil, Vikas
    Milsom, Alexandra B.
    Okorie, Michael
    Maleki-Toyserkani, Sheiva
    Akram, Farihah
    Rehman, Farkhanda
    Arghandawi, Shah
    Pearl, Vanessa
    Benjamin, Nigel
    Loukogeorgakis, Stavros
    MacAllister, Raymond
    Hobbs, Adrian J.
    Webb, Andrew J.
    Ahluwalia, Amrita
    HYPERTENSION, 2010, 56 (02) : 274 - U174
  • [28] Training Status in Older Men Affects Transcriptional Responsiveness Following Skeletal Muscle Damage
    Buford, Thomas W.
    Cooke, Matthew B.
    Redd, Liz L.
    Shelmadine, Brian D.
    Hudson, Geoffrey M.
    Willoughby, Darryn S.
    MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, 2010, 42 (05): : 823 - 824
  • [29] Inorganic Nitrate Supplementation Increases Skeletal Muscle Perfusion And Metabolism During Exercise In Peripheral Arterial Disease
    Derella, Cassandra C.
    de Zevallos, Joaquin Ortiz
    Sporkin, Helen L.
    Nealy, Zachariah
    Hogwood, Austin C.
    Patel, Toral R.
    Kaso, Elona Rrapo
    Meyer, Craig H.
    Kramer, Christopher M.
    Weltman, Arthur L.
    Allen, Jason D.
    MEDICINE & SCIENCE IN SPORTS & EXERCISE, 2024, 56 (10) : 154 - 154
  • [30] Sex-based differences in the blood pressure responses to muscle metaboreflex activation are consistent between limb and respiratory muscle
    Benbaruj, Jenna M.
    Leahy, Michael G.
    Jackman, Rachel
    Rae, Thora
    Boushel, Robert
    Foster, Glen E.
    Sheel, A. William
    JOURNAL OF APPLIED PHYSIOLOGY, 2024, 137 (05) : 1220 - 1230