RETRACTED: TWO MIXED-LIGAND Cu(II) COORDINATION POLYMERS: PROTECTIVE EFFECT ON SEPSIS BY REDUCING AN EXCESSIVE INFLAMMATORY RESPONSE (Retracted article. See vol. 64, pg. 528, 2023)

By the reaction of a rigid pi-conjugated H4L linker (5,5 '-(1,3,6,8-tetraoxobenzo[lmn][3],[8]phenanthroline-2-7-diyl)bis-1,3-benzenedicarboxylic acid), Cu(NO3)(2), and N-donor auxiliary linkers, two new Cu-based coordination polymers (CPs), namely {[Cu(L)(0.5)(1,4-bib)(H2O)(2)]center dot 0.5H(2)O}(n) (1) and {[Cu(H2L)(4,4 '-bibp)(H2O)(2)]}(n) (2) {1,4-bib = 1,4-bis(1-imidazolyl)benzene, 4,4 '-bibp = 4,4 '-bis(imidazolyl)biphenyl} are synthesized under solvothermal conditions and characterized. Furthermore, the protective effect of compounds 1 and 2 on the sepsis mice model is evaluated and the related mechanism is explored. Firstly, the CFU counting assay is performed to detect the bactericidal effect of compounds 1 and 2 in vivo. Then, the ELISA assay is conducted to measure the release of interleukin-1 beta (IL-1 beta) and interleukin-6 (IL-6) into the plasma after treatment with the compounds.