Giant cell arteritis with ocular involvement successfully treated with tocilizumab and very short-course glucocorticoids: A case report

被引：3
|
作者：
Khanna, R. K. [1 ]
Hage, R. [1 ]
Lecler, A. [2 ]
Sene, T. [3 ]
Vignal-Clermont, C. [1 ]
Clavel-Refregiers, G. [3 ]
机构：
[1] Fdn Adolphe de Rothschild Hosp, Dept Ophthalmol, 29 Rue Manin, F-75019 Paris, France
[2] Fdn Adolphe de Rothschild Hosp, Dept Neuroradiol, Paris, France
[3] Fdn Adolphe de Rothschild Hosp, Dept Internal Med, Paris, France
来源：
JOURNAL FRANCAIS D OPHTALMOLOGIE | 2021年 / 44卷 / 04期
关键词：
Giant cell arteritis; Tocilizumab; IL-6; Glucocorticoids; Anterior ischemic optic neuropathy;
D O I：
10.1016/j.jfo.2020.08.028
中图分类号：
R77 [眼科学];
学科分类号：
100212 ;
摘要：
Purpose. - To report the case of a patient with arteritic anterior ischemic optic neuropathy (AAION) with a history of glucocorticoids (GC) hypersensitivity treated with monthly intravenous tocilizumab (IV TCZ) and short course of GC. Case report. - A 71-year-old Caucasian patient presented with AAION related to giant cell arteritis (GCA) confirmed by temporal artery biopsy. Past medical history was significant for GC hypersensitivity proven by allergy evaluation and the patient was managed with IV TCZ and very short-course GC. Conclusion. - TCZ therapy with very short-course GC could be effective in GCA with ophthalmic involvement as a first-line strategy. Clinical trials are needed for thorough evaluation of the efficiency of TCZ as a first-line treatment to induce and maintain remission in patients with GCA and ocular involvement. (C) 2021 Elsevier Masson SAS. All rights reserved.
引用
收藏
页码：481 / 484
页数：4
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