Chiral primary amine mediated conjugate addition of branched aldehydes to vinyl sulfone: asymmetric generation of quaternary carbon centers

被引：84

作者：

Zhu, Qiang ^{[1
,2
]}

Lu, Yixin ^{[1
,2
]}

机构：

[1] Natl Univ Singapore, Dept Chem, Singapore 117543, Singapore

[2] Natl Univ Singapore, Med Chem Program, Inst Life Sci, Singapore 117543, Singapore

来源：

CHEMICAL COMMUNICATIONS | 2010年 / 46卷 / 13期

关键词：

ORGANOCATALYTIC MICHAEL ADDITION; SELECTIVE MANNICH REACTIONS; DIRECT ALDOL REACTION; ALPHA; ALPHA-DISUBSTITUTED ALDEHYDES; ENANTIOSELECTIVE ORGANOCATALYSIS; THIOUREA CATALYST; CONSTRUCTION; KETONES; STEREOCENTERS; DERIVATIVES;

D O I：

10.1039/b919549a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Novel L-threonine-derived bifunctional organic catalysts containing primary amine and sulfonamide groups were utilized to promote asymmetric conjugate addition of alpha,alpha-disubstitued aldehydes to 1,1-bis(benzenesulfonyl)ethylene. The adducts with quaternary stereogenic centers adjacent to an aldehyde group were obtained in high yield and with good enantioselectivity.

引用

页码：2235 / 2237

页数：3

共 36 条

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