Uncoupling of neurogenesis and differentiation during retinal development

被引:14
|
作者
Engerer, Peter [1 ]
Suzuki, Sachihiro C. [2 ,8 ]
Yoshimatsu, Takeshi [2 ,9 ]
Chapouton, Prisca [3 ]
Obeng, Nancy [1 ]
Odermatt, Benjamin [4 ]
Williams, Philip R. [1 ,10 ]
Misgeld, Thomas [1 ,5 ,6 ,7 ]
Godinho, Leanne [1 ]
机构
[1] Tech Univ Munich, Inst Neuronal Cell Biol, Munich, Germany
[2] Univ Washington, Dept Biol Struct, Seattle, WA 98195 USA
[3] Helmholtz Zentrum Munchen, German Res Ctr Environm Hlth, Sensory Biol & Organogenesis, Neuherberg, Germany
[4] Rhein Friedrich Wilhelms Univ Bonn, Anatom Inst, Bonn, Germany
[5] Ctr Integrated Prot Sci CIPSM, Munich, Germany
[6] German Ctr Neurodegenerat Dis DZNE, Munich, Germany
[7] Munich Cluster Syst Neurol SyNergy, Munich, Germany
[8] Grad Univ, Okinawa Inst Sci & Technol, Technol Licensing Sect, Okinawa, Japan
[9] Univ Sussex, Sch Life Sci, Sussex Neurosci, Brighton, E Sussex, England
[10] Harvard Med Sch, Childrens Hosp Boston, FM Kirby Neurobiol Ctr, Dept Neurol, Boston, MA 02115 USA
来源
EMBO JOURNAL | 2017年 / 36卷 / 09期
基金
欧洲研究理事会;
关键词
bipolar cells; development; differentiation; neurogenesis; retina; SYMMETRIC DIVISIONS; PRECURSOR CELLS; NEURONS ARISE; ZEBRAFISH; MITOSIS; GENES; PROGENITORS; EXPRESSION; MIGRATION; SYNAPSES;
D O I
10.15252/embj.201694230
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Conventionally, neuronal development is regarded to follow a stereotypic sequence of neurogenesis, migration, and differentiation. We demonstrate that this notion is not a general principle of neuronal development by documenting the timing of mitosis in relation to multiple differentiation events for bipolar cells (BCs) in the zebrafish retina using in vivo imaging. We found that BC progenitors undergo terminal neurogenic divisions while in markedly disparate stages of neuronal differentiation. Remarkably, the differentiation state of individual BC progenitors at mitosis is not arbitrary but matches the differentiation state of post-mitotic BCs in their surround. By experimentally shifting the relative timing of progenitor division and differentiation, we provide evidence that neurogenesis and differentiation can occur independently of each other. We propose that the uncoupling of neurogenesis and differentiation could provide neurogenic programs with flexibility, while allowing for synchronous neuronal development within a continuously expanding cell pool.
引用
收藏
页码:1134 / 1146
页数:13
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