A comparison of histidine protecting groups in the synthesis of peptide-oligonucleotide conjugates

被引：24
|
作者：
Beltrán, M [1 ]
Pedroso, E [1 ]
Grandas, A [1 ]
机构：
[1] Univ Barcelona, Fac Quim, Dept Quim Organ, E-08028 Barcelona, Spain
来源：
TETRAHEDRON LETTERS | 1998年 / 39卷 / 23期
关键词：
D O I：
10.1016/S0040-4039(98)00669-8
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Protection of the imidazole ring of the histidine residue is not required for the elongation of an oligonucleotide chain at the side chain hydroxyl group of an amino acid residue by the phosphite triester approach. For the assembly of the peptide chain, the 2,4-dinitrophenyl group is the best alternative when histidine is placed at the C-terminal position. (C) 1998 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：4115 / 4118
页数：4
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