Review of ultrasensitive readout for micro-/nanofluidic devices by thermal lens microscopy

被引:3
|
作者
Chen, Chihchen [1 ]
Shimizu, Hisashi [2 ]
Kitamori, Takehiko [1 ,2 ]
机构
[1] Natl Tsing Hua Univ, Inst Nanoengn & Microsyst, Dept Power Mech Engn, Hsinchu, Taiwan
[2] Univ Tokyo, Dept Mech Engn, Res Org Micronano Multi Funct Device, Bunkyo, Tokyo, Japan
来源
JOURNAL OF OPTICAL MICROSYSTEMS | 2021年 / 1卷 / 02期
关键词
thermal lens microscopy; microfluidics; nanofluidics; photothermal spectroscopy; thermal lens spectrometry; gradient-index lens; LABEL-FREE DETECTION; PHASE SHIFT DETECTION; ON-CHIP INTEGRATION; SENSITIVE DETERMINATION; THERMOOPTICAL DETECTION; IMMUNOASSAY SYSTEM; HIGH-THROUGHPUT; LIQUID; NANOPARTICLES; SPECTROMETER;
D O I
10.1117/1.JOM.1.2.020901
中图分类号
O43 [光学];
学科分类号
070207 ; 0803 ;
摘要
Thermal lens microscopy (TLM) utilizes the effects, such as changes in the refractive index, caused by heat generated in the sample for the detection of nonfluorescent analytes with at least a hundred-fold enhancement in sensitivity compared with optical absorbance spectrometry. Micro-/nanofluidic devices can provide specificity and sample manipulation capabilities. The integration of these two technologies exposes the potential to attain the holy grail of continuous, real-time, label-free, specific, and ultrasensitive detection, which find applications in environmental monitoring, quality control of chemical manufacturing, single-cell analysis, and biomedicines. Here, we summarize the recent advances in the instrument development and innovative applications, and suggest future directions of research of TLM. (C) The Authors. Published by SPIE under a Creative Commons Attribution 4.0 Unported License.
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页数:13
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