First Total Synthesis of a Cytotoxic Derivative of the Natural Product Aaptamine

被引：2

作者：

Puvvala, Srinu ^{[1
,2
]}

Jadhav, Vinod D. ^{[1
]}

Narkhede, Umesh C. ^{[1
]}

Karun, M. V. V. S. R. N. Anji ^{[1
]}

Reddy, Ch. Venkata Ramana ^{[2
]}

机构：

[1] GVK Biosci Pvt Ltd, Chem Serv, IDA Nacharam, Hyderabad 500076, Andhra Pradesh, India

[2] Jawaharlal Nehru Technol Univ, Dept Chem, Hyderabad 500085, Andhra Pradesh, India

来源：

SYNTHESIS-STUTTGART | 2017年 / 49卷 / 12期

关键词：

total synthesis; heterocycles; vicarious aromatic substitution; cyclization; alkylation; SPONGE AAPTOS-AAPTOS; ALKALOIDS; DESIGN; POTENT; INHIBITORS; DISCOVERY; OXIDATION; EFFICIENT;

D O I：

10.1055/s-0036-1588752

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A synthetic sequence to the benzonaphthyridinone framework is described. The key step is a one-pot, base-catalyzed vicarious nucleophilic substitution followed by ring closure. Additionally, the synthesis represents the application of a vicarious nucleophilic substitution in the total synthesis of a cytotoxic aaptamine derivative.

引用

页码：2768 / 2774

页数：7

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