First Total Synthesis of a Cytotoxic Derivative of the Natural Product Aaptamine

被引：2
|
作者：
Puvvala, Srinu [1 ,2 ]
Jadhav, Vinod D. [1 ]
Narkhede, Umesh C. [1 ]
Karun, M. V. V. S. R. N. Anji [1 ]
Reddy, Ch. Venkata Ramana [2 ]
机构：
[1] GVK Biosci Pvt Ltd, Chem Serv, IDA Nacharam, Hyderabad 500076, Andhra Pradesh, India
[2] Jawaharlal Nehru Technol Univ, Dept Chem, Hyderabad 500085, Andhra Pradesh, India
来源：
SYNTHESIS-STUTTGART | 2017年 / 49卷 / 12期
关键词：
total synthesis; heterocycles; vicarious aromatic substitution; cyclization; alkylation; SPONGE AAPTOS-AAPTOS; ALKALOIDS; DESIGN; POTENT; INHIBITORS; DISCOVERY; OXIDATION; EFFICIENT;
D O I：
10.1055/s-0036-1588752
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A synthetic sequence to the benzonaphthyridinone framework is described. The key step is a one-pot, base-catalyzed vicarious nucleophilic substitution followed by ring closure. Additionally, the synthesis represents the application of a vicarious nucleophilic substitution in the total synthesis of a cytotoxic aaptamine derivative.
引用
收藏
页码：2768 / 2774
页数：7
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