Fengycin A Analogues with Enhanced Chemical Stability and Antifungal Properties

被引：26
|
作者：
Gimenez, Diana [1 ]
Phelan, Aoife [2 ]
Murphy, Cormac D. [2 ]
Cobb, Steven L. [1 ]
机构：
[1] Univ Durham, Dept Chem, Durham DH1 3LE, England
[2] Univ Coll Dublin, Sch Biomol & Biomed Sci, Dublin 4, Ireland
来源：
ORGANIC LETTERS | 2021年 / 23卷 / 12期
基金：
爱尔兰科学基金会; 英国生物技术与生命科学研究理事会;
关键词：
BACILLUS-SUBTILIS; SURFACTIN ITURIN; LIPOPEPTIDES; AMYLOLIQUEFACIENS;
D O I：
10.1021/acs.orglett.1c01387
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Fengycins are cyclic lipo-depsipeptides produced by Bacillus spp. that display potent antifungal properties but are chemically unstable. This instability has meant that no total synthesis of any fengycin has been published. Here we report the synthesis of fengycin A analogues that display enhanced antifungal properties and chemical stability under both basic and acidic conditions. The analogues prepared also demonstrate that the fengycin core structure can be modified and simplified without the loss of antifungal activity.
引用
收藏
页码：4672 / 4676
页数：5
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