Monocyte cell membrane-derived nanoghosts for targeted cancer therapy

被引：118
|
作者：
Krishnamurthy, S. [1 ,2 ]
Gnanasammandhan, M. K. [3 ]
Xie, C. [1 ,2 ]
Huang, K. [3 ]
Cui, M. Y. [1 ,2 ]
Chan, J. M. [1 ,2 ]
机构：
[1] Nanyang Technol Univ, Sch Chem & Biomed Engn, Block N1-3,B4-10,70 Nanyang Dr, Singapore 637457, Singapore
[2] Nanyang Technol Univ, Lee Kong Chian Sch Med, Block N1-3,B4-10,70 Nanyang Dr, Singapore 637457, Singapore
[3] Natl Univ Singapore, Dept Biomed Engn, 9 Engn Dr 1,Block EA,03-12, Singapore 117575, Singapore
来源：
NANOSCALE | 2016年 / 8卷 / 13期
关键词：
ERYTHROCYTE-MEMBRANE; POLYMERIC NANOPARTICLES; DELIVERY; CARRIER; ADSORPTION; CIRCULATION; DOXORUBICIN; ADENOVIRUS;
D O I：
10.1039/c5nr07588b
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Core-shell type 'nanoghosts' were synthesized with a drug-loaded biodegradable PLGA core and a monocyte cell membrane-derived shell. The nanoghosts were monodisperse with an average size <200 nm, and showed good serum stability for 120 h. Doxorubicin-loaded nanoghosts showed greater cellular uptake and cytotoxicity compared to non-coated nanoparticle controls in metastatic MCF-7 breast cancer cell lines.
引用
收藏
页码：6981 / 6985
页数：5
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