One-Pot Three-Component Synthesis of 3-Aminoalkyl Indoles Catalyzed by Molecular Iodine

被引：9
|
作者：
Depa, Navaneetha [2 ]
Erothu, Harikrishna [1 ,2 ]
机构：
[1] KLEF, Dept Chem, CAES, Guntur 522502, Andhra Pradesh, India
[2] KLEF, Dept Chem, Guntur 522502, Andhra Pradesh, India
来源：
CHEMISTRYSELECT | 2019年 / 4卷 / 33期
关键词：
3-aminoalkyl indole; aniline; ethanol; iodine; one-pot three-component reaction; FRIEDEL-CRAFTS ALKYLATION; SOLVENT-FREE; MULTICOMPONENT SYNTHESIS; METAL-FREE; FACILE SYNTHESIS; DOMINO REACTION; EFFICIENT; DERIVATIVES; KETONES; ALCOHOLS;
D O I：
10.1002/slct.201902832
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A facile one-pot three-component coupling (3CC) of indoles, aldehydes, and N-alkyl anilines has been attained using a catalytic quantity of molecular iodine under neutral conditions to afford 3-aminoalkyl indoles at room temperature. The salient features of this method are the mild reaction conditions, the operational simplicity of the method, outstanding yields in moderately at short reaction times and low cost of the catalyst.
引用
收藏
页码：9722 / 9725
页数：4
相关论文
共 50 条
  • [31] Direct selenation of imidazoheterocycles and indoles with selenium powder in a copper-catalyzed three-component one-pot system
    Guo, Tao
    Dong, Zhe
    Zhang, Panke
    Xing, Weiqin
    Li, Liping
    TETRAHEDRON LETTERS, 2018, 59 (26) : 2554 - 2558
  • [32] Three-component one-pot reaction for the synthesis of β-amide ketones
    Luo, Yan-Ping
    Chen, Qiong
    CHEMICAL PAPERS, 2013, 67 (05) : 532 - 537
  • [33] A Photochemical One-Pot Three-Component Synthesis of Tetrasubstituted Imidazoles
    Pusch, Stefan
    Opatz, Till
    ORGANIC LETTERS, 2014, 16 (20) : 5430 - 5433
  • [34] One-Pot Three-Component Approach to the Synthesis of Polyfunctional Pyrazoles
    Zhang, Guolin
    Ni, Hangcheng
    Chen, Wenteng
    Shao, Jiaan
    Liu, Huan
    Chen, Binhui
    Yu, Yongping
    ORGANIC LETTERS, 2013, 15 (23) : 5967 - 5969
  • [35] One-pot three-component reaction for the synthesis of α-(aminoethyl)-α,β-enones
    Bertozzi, F
    Gustafsson, M
    Olsson, R
    ORGANIC LETTERS, 2002, 4 (24) : 4333 - 4336
  • [36] One-Pot Three-Component Synthesis of 3,4-Dihydroquinazoline Derivatives
    Zhao Long
    Yang Maolin
    Chen Haoran
    Ding Mingwu
    CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2022, 42 (11) : 3740 - 3746
  • [37] AN EFFICIENT THREE-COMPONENT ONE-POT SYNTHESIS OF PYRIMIDOBENZIMIDAZOLE DERIVATIVES
    Kumar, Goda Pankaja
    Sekhar, Thuraka
    Thriveni, Pinnu
    Venkateswarlu, Annavarapu
    Reddy, Peduri Suresh
    HETEROCYCLIC LETTERS, 2021, 11 (02): : 231 - 236
  • [38] One-pot, three-component synthesis of arylidenesuccinates and related compounds
    McCombie, SW
    Luchaco, CA
    TETRAHEDRON LETTERS, 1997, 38 (33) : 5775 - 5776
  • [39] One-pot three-component catalytic asymmetric synthesis of homoallylboronates
    Ibrahem, Ismail
    Afewerki, Samson
    Breistein, Palle
    Cordova, Armando
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2012, 243
  • [40] A novel, one-pot and three-component synthesis of α-quinoxalinyl triphenylphosphoranes
    Adib, Mehdi
    Sheibani, Esmaeil
    Abbasi, Alireza
    Bijanzadeh, Hamid Reza
    TETRAHEDRON LETTERS, 2007, 48 (07) : 1179 - 1182
12345