One-Pot Three-Component Synthesis of 3-Aminoalkyl Indoles Catalyzed by Molecular Iodine

被引：9

作者：

Depa, Navaneetha ^{[2
]}

Erothu, Harikrishna ^{[1
,2
]}

机构：

[1] KLEF, Dept Chem, CAES, Guntur 522502, Andhra Pradesh, India

[2] KLEF, Dept Chem, Guntur 522502, Andhra Pradesh, India

来源：

CHEMISTRYSELECT | 2019年 / 4卷 / 33期

关键词：

3-aminoalkyl indole; aniline; ethanol; iodine; one-pot three-component reaction; FRIEDEL-CRAFTS ALKYLATION; SOLVENT-FREE; MULTICOMPONENT SYNTHESIS; METAL-FREE; FACILE SYNTHESIS; DOMINO REACTION; EFFICIENT; DERIVATIVES; KETONES; ALCOHOLS;

D O I：

10.1002/slct.201902832

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A facile one-pot three-component coupling (3CC) of indoles, aldehydes, and N-alkyl anilines has been attained using a catalytic quantity of molecular iodine under neutral conditions to afford 3-aminoalkyl indoles at room temperature. The salient features of this method are the mild reaction conditions, the operational simplicity of the method, outstanding yields in moderately at short reaction times and low cost of the catalyst.

引用

页码：9722 / 9725

页数：4

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