A Convenient Synthesis of 3,3-Bis(thienyl)propionic Acids by Platinum (II)-Catalyzed Reaction of Thiophenes with Propiolic Acids

被引：2

作者：

Kitamura, Tsugio ^{[1
]}

Mizuhara, Tomonobu ^{[1
]}

Keita, Mory Laye ^{[1
]}

Oyamada, Juzo ^{[1
]}

机构：

[1] Saga Univ, Fac Sci & Engn, Dept Chem & Appl Chem, Honjo, Saga 8408502, Japan

来源：

PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS | 2010年 / 185卷 / 5-6期

关键词：

Hydroarylation; platinum catalyst; propiolic acids; thiophenes; C-H BONDS; ACTIVATION; HYDROARYLATION; FUNCTIONALIZATION; EFFICIENT; ALKYNES;

D O I：

10.1080/10426501003773514

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Platinum(II)-catalyzed hydroarylation of propiolic acids was applied to thiophenes, and we found that the reaction with thiophenes predominantly afforded double thienylated products. Reaction of thiophenes with ethyl propiolate proceeded efficiently in the presence of K2PtCl4 (2 mol%) and AgOTf (8 mol%) in trifluoroacetic acid under mild conditions to give ethyl 3,3-bis(substituted thienyl)propionates in good yields. The same platinum(II)-catalyzed reaction with propiolic acid instead of the ethyl ester provided bis(substituted thienyl)propionic acids in high yields.

引用

页码：1154 / 1161

页数：8

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