Hyperthyroidism as a manifestation of gestational trophoblastic disease: A case report

Gestational trophoblastic disease (GTD) is a group of tumours caused by the hyper-proliferation of trophobtast cells and is noted for its overproduction of hCG. Among its manifestations, there may be hyperthyroidism, due to the stimulating activity of hCG on TSH receptors. In most cases it is only a biochemical hyperthyroidism, with its presentation as symptomatic hyperthyroidism being much less frequent. We report the case of a patient with GTD, who at diagnosis presented with symptomatic hyperthyroidism. Treatment included surgical evacuation of the hydatidiform mole, as well as a beta-blocker and antithyroid drug treatment to relieve the symptoms. (C) 2019 Elsevier Espana, S.L.U. All rights reserved.