Expression of MMPs and TIMPs in liver fibrosis - a systematic review with special emphasis on anti-fibrotic strategies

被引：393
|
作者：
Hemmann, Stefanie
Graf, Juergen
Roderfeld, Martin
Roeb, Elke
机构：
[1] Univ Hosp Giessen & Marburg GmbH, Dept Med 2, D-35392 Giessen, Germany
[2] Univ Hosp Giessen & Marburg GmbH, Dept Anaesthesiol & Intens Care, D-35033 Marburg, Germany
来源：
JOURNAL OF HEPATOLOGY | 2007年 / 46卷 / 05期
关键词：
liver; fibrosis; MMP; TIMP; matrix; metalloproteinase; tissue; inhibitor; therapy; expression;
D O I：
10.1016/j.jhep.2007.02.003
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
In liver tissue matrix metalloproteinases (MMPs) and their specific inhibitors (tissue inhibitors of metalloproteinases, TIMPs) play a pivotal role in both, fibrogenesis and fibrolysis. The current knowledge of the pathophysiology of liver fibrogenesis with special emphasis on MMPs and TIMPs is presented. A systematic literature search was conducted. All experimental models of liver fibrosis that evaluated a defined anti-fibrotic intervention in vivo or in vitro considering MMPs and TIMPs were selected. The methodological quality of all these publications has been critically appraised using an objective scoring system and the content has been summarized in a table. (C) 2007 European Association for the Study of the Liver. Published by Elsevier BN. All rights reserved.
引用
收藏
页码：955 / 975
页数：21
相关论文
共 50 条
  • [21] NANOPARTICULAR BISPHOSPHONATE TO SELECTIVELY TARGET AND REPOLARIZE LIVER MACROPHAGES FOR ANTI-FIBROTIC RESPONSES IN experimental LIVER FIBROSIS
    Kaps, Leonard
    Nuhn, Lutz
    Choteschovsky, Niklas
    Klefenz, Adrian
    Aslam, Misbah, Jr.
    Zentel, Rudolf
    Schuppan, Detlef
    HEPATOLOGY, 2019, 70 : 1127A - 1127A
  • [22] Adult human liver slice cultures: Modelling of liver fibrosis and evaluation of new anti-fibrotic drugs
    Daria Kartasheva-Ebertz
    Jesintha Gaston
    Loriane Lair-Mehiri
    Pierre-Philippe Massault
    Olivier Scatton
    Jean-Christophe Vaillant
    Vladimir Alexei Morozov
    Stanislas Pol
    Sylvie Lagaye
    World Journal of Hepatology, 2021, 13 (02) : 187 - 217
  • [23] Adult human liver slice cultures: Modelling of liver fibrosis and evaluation of new anti-fibrotic drugs
    Kartasheva-Ebertz, Daria
    Gaston, Jesintha
    Lair-Mehiri, Loriane
    Massault, Pierre-Philippe
    Scatton, Olivier
    Vaillant, Jean-Christophe
    Morozov, Vladimir Alexei
    Pol, Stanislas
    Lagaye, Sylvie
    WORLD JOURNAL OF HEPATOLOGY, 2021, 13 (02) : 187 - 217
  • [24] The anti-inflammatory and anti-fibrotic effects of tadalafil in thioacetamide-induced liver fibrosis in rats
    Mansour, Heba M.
    Salama, Abeer A. A.
    Abdel-Salam, Rania M.
    Ahmed, Naglaa A.
    Yassen, Noha N.
    Zaki, Hala F.
    CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, 2018, 96 (12) : 1308 - 1317
  • [25] Impact of anti-fibrotic medications on post-COVID-19 pulmonary fibrosis: A systematic review and meta-analysis
    Shu, Yizhou
    He, Lixiu
    Liu, Chuntao
    INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, 2024, 147
  • [26] A review of Idiopathic Pulmonary Fibrosis patients on anti-fibrotic treatment in the mid west area
    Ryan, N.
    Ryan, P.
    Gleeson, E.
    Cullinan, M.
    Mcinerney, C.
    Casserly, B.
    O'Brien, A.
    IRISH JOURNAL OF MEDICAL SCIENCE, 2017, 186 (SUPPL 10) : S441 - S442
  • [27] Anti-apoptotic and anti-fibrotic efficacy of exercise training in hypertensive hearts: A systematic review
    Akbar, Adjar Yusrandi
    Cui, Zhen-Yang
    Hsu, Che-Jui
    Li, Yan-Zhang
    Rahman, Ferry Fadzlul
    Xia, Chunqiu
    Yang, Ai-Lun
    Lee, Shin-Da
    FRONTIERS IN CARDIOVASCULAR MEDICINE, 2023, 10
  • [28] Anti-fibrotic effects of fresh and cryopreserved human amniotic membrane in a rat liver fibrosis model
    Ricci, Emanuele
    Vanosi, Graziella
    Lindenmair, Andrea
    Hennerbichler, Simone
    Peterbauer-Scherb, Anja
    Wolbank, Susanne
    Cargnoni, Anna
    Signoroni, Patrizia Bonassi
    Campagnol, Marino
    Gabriel, Christian
    Redl, Heinz
    Parolini, Ornella
    CELL AND TISSUE BANKING, 2013, 14 (03) : 475 - 488
  • [29] Anti-fibrotic effects of fresh and cryopreserved human amniotic membrane in a rat liver fibrosis model
    Emanuele Ricci
    Graziella Vanosi
    Andrea Lindenmair
    Simone Hennerbichler
    Anja Peterbauer-Scherb
    Susanne Wolbank
    Anna Cargnoni
    Patrizia Bonassi Signoroni
    Marino Campagnol
    Christian Gabriel
    Heinz Redl
    Ornella Parolini
    Cell and Tissue Banking, 2013, 14 : 475 - 488
  • [30] UNEXPECTED ANTI-FIBROTIC EFFECTS OF MACROPHAGE MIGRATION INHIBITORY FACTOR (MIF) IN EXPERIMENTAL LIVER FIBROSIS
    Heinrichs, D.
    Jung, M.
    Offermanns, C.
    Schmitz, P.
    Trautwein, C.
    Bernhagen, J.
    Wasmuth, H. E.
    JOURNAL OF HEPATOLOGY, 2010, 52 : S365 - S365
12345