Soft tissue perineuromas in children: Report of three cases and review of the literature

Perineuromas (PN) are uncommon, slowly growing, usually benign tumors composed of well-differentiated perineural cells. Two variants are recognized: intraneural perineuromas and soft tissue perineuroma, which includes a sclerosing subset of tumors. They are usually reported in the adult population. We present three cases of soft tissue perineuromas in children. One was located in the deep soft tissue of the retroperitoneum in a 14-year-old girl, the second one in the left thumb of a 14-year-old boy, and the third one in the index finger of a 16-year-old boy. This report, which describes the clinicopathologic, immunohistochemical, and ultrastructural features of these tumors, should alert pathologists to the occurrence of perineuromas in children. A review of the English language literature on perineuromas in children is also included.