Asymmetric Nazarov Reaction Catalyzed by Chiral Tris(oxazoline)/Copper(II)

被引：104
|
作者：
Cao, Peng [1 ]
Deng, Chao [1 ]
Zhou, You-Yun [1 ]
Sun, Xiu-Li [1 ]
Zheng, Jun-Cheng [1 ]
Xie, Zuowei [2 ]
Tang, Yong [1 ]
机构：
[1] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China
[2] Chinese Univ Hong Kong, Dept Chem, Shatin, Hong Kong, Peoples R China
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2010年 / 49卷 / 26期
关键词：
asymmetric catalysis; copper; cyclization; diastereoselectivity; Nazarov cyclization; MICHAEL ADDITION; ENANTIOSELECTIVE HYDROGENATION; STEREOSELECTIVE-SYNTHESIS; EFFICIENT CATALYSIS; THREEFOLD SYMMETRY; CYCLIZATION; COMPLEXES; LIGANDS; (+/-)-MERRILACTONE-A; REARRANGEMENT;
D O I：
10.1002/anie.200907266
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
(Figure Presented) Beverly Hills copper(II): A highly efficient catalytic asymmetric Nazarov reaction has been developed through control of the enantioselectivity of the cyclization step, affording chiral O-heterohexahydroinde-nones in excellent yields with excellent enantioselectivity and diastereoselectivity. HFIP = hexafluoro-2-propanol, BArF = tetrakis[3,5-bis(trifluoromethyl)phenyl] borate. © 2010 Wlley-VCH Verlag GmbH &. Co. KGaA, Weinheim.
引用
收藏
页码：4463 / 4466
页数：4
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