Mathematical modeling of low-frequency oscillations induced by modulated noise in human microvasculature

A mathematical hydrodynamic model of human cardiovascular bed has been developed. The model includes a 4-chamber heart, two circles of blood circulation and a multilevel microvasculature. Using model developed we studied the influence of low-intensity noise on blood flow oscillations in microvascular bed. In the study low-intensity noise effects on heart wall tone of left ventricle. Unmodulated noise and noise modulated by a sine with frequencies of 0.02, 0.0625 and 0.1 Hz were used. Unmodulated noise induced the forming of low-frequency oscillations of microvascular blood flow with a peak at the frequency of 0.1 Hz. Modulated noise induced low-frequency oscillations of blood flow with pronounced peaks at the modulation frequencies. The obtained results indicate a detecting property of simulated vascular bed that allows one to define modulating signal. This behavior is a characteristic of the system consisting of nonlinear and filtering components.