[1] Case Western Reserve Univ, Cleveland Inst Computat Biol, Dept Populat & Quantitat Hlth Sci, Cleveland, OH 44106 USA
[2] Case Western Reserve Univ, Cleveland Inst Computat Biol, Dept Genet & Genome Sci, Cleveland, OH 44106 USA
[3] Univ Penn, Inst Syst Pharmacol & Translat Therapeut, Philadelphia, PA 19104 USA
[4] Univ Penn, Div Translat Med & Human Genet, Perelman Sch Med, Philadelphia, PA 19104 USA
[5] Univ Penn, Dept Genet, Perelman Sch Med, Philadelphia, PA 19104 USA
[6] Univ Penn, Dept Biol, Sch Arts & Sci, Philadelphia, PA 19104 USA