Structural and DNA cleavage of sugar-derived Schiff base ligands and their dinuclear Cu(II) complexes

被引：11
|
作者：
Nagarajan, Subbiah [1 ]
Kumbhar, Anupa [2 ]
Varghese, Babu [3 ]
Das, Thangamuthu Mohan [1 ]
机构：
[1] Univ Madras, Dept Organ Chem, Madras 600025, Tamil Nadu, India
[2] Univ Pune, Dept Chem, Pune 4111007, Maharashtra, India
[3] Indian Inst Technol, Single Crystal XRD Lab, SAIF, Madras 600036, Tamil Nadu, India
来源：
CARBOHYDRATE RESEARCH | 2010年 / 345卷 / 09期
关键词：
4,6-O-Benzylidene-D-glucopyranose; 4,6-O-Butylidene-D-glucopyranose; N-Glycosyl amines; Cu(II)-complexes; DNA cleavage; Single-crystal XRD; TETRANUCLEAR COPPER(II) COMPLEXES; PRIMARY ALCOHOLS; BUILDING-BLOCKS; COORDINATION; TRINUCLEAR; BINDING; DERIVATIVES; ACTIVATION; REACTIVITY; IONS;
D O I：
10.1016/j.carres.2010.01.010
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Neutral dinuclear Cu(II) complexes of Schiff base ligands derived from D-glucose have been synthesized and structurally characterized. These complexes were evaluated for their interaction with DNA, and DNA cleavage was observed even in the presence of radical inhibitors. (C) 2010 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1077 / 1083
页数：7
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