Raltitrexed (Tomudex):: an alternative drug for patients with colorectal cancer and 5-fluorouracil associated cardiotoxicity

被引：62
|
作者：
Köhne, CH
Thuss-Patience, P
Friedrich, M
Daniel, PT
Kretzschmar, A
Benter, T
Bauer, B
Dietz, R
Dörken, B
机构：
[1] Humboldt Univ, Med Fak Charite, Virchow Klinikum,Robert Rossle Klin, Dept Haematol Oncol & Tumor Immunol, D-13125 Berlin, Germany
[2] Humboldt Univ, Med Fak Charite, Virchow Klinikum,Franz Volhard Klin, Dept Clin & Mol Cardiol, D-13125 Berlin, Germany
来源：
BRITISH JOURNAL OF CANCER | 1998年 / 77卷 / 06期
关键词：
5-fluorouracil; cardiotoxicity; raltitrexed; colorectal neoplasms;
D O I：
10.1038/bjc.1998.160
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Two patients with proven 5-fluorouracil (5-FU)-associated cardiotoxicity were treated with the specific thymidylate synthase inhibitor raltitrexed safely, without evidence of cardiotoxicity. Raltitrexed might be an alternative for patients with advanced colorectal cancer and 5-FU-associated cardiotoxicity. 5-FU cardiotoxicity is not due to the antineoplastic mechanisms via thymidilate synthase.
引用
收藏
页码：973 / 977
页数：5
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