Protein Kinase C/Mitogen-Activated Protein Kinase Signaling in Keratinocyte Differentiation control

被引：9
|
作者：
Denning, Mitchell F. [1 ,2 ]
机构：
[1] Loyola Univ, Skin Canc Res Program, Dept Pathol, Maywood, IL 60153 USA
[2] Loyola Univ, Skin Canc Res Program, Cardinal Bernardin Canc Ctr, Maywood, IL 60153 USA
来源：
JOURNAL OF INVESTIGATIVE DERMATOLOGY | 2010年 / 130卷 / 08期
关键词：
INVOLUCRIN GENE; C-DELTA; FILAGGRIN;
D O I：
10.1038/jid.2010.194
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
Proper epidermal keratinocyte differentiation, which is necessary for cutaneous barrier function, is altered in many common skin diseases. Keratinocyte differentiation is controlled by a complex signaling network involving multiple members of the protein kinase c and mitogen-activated protein kinase signaling kinases. Using an RNA interference knockdown approach, Adhikary et al. identified essential nodes in this signaling network, revealing remarkable kinase specificity.
引用
收藏
页码：1968 / 1970
页数：4
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