Idebenone treatment in Friedreich patients: One-year-long randomized placebo-controlled trial

被引：156
|
作者：
Mariotti, C
Solari, A
Torta, D
Marano, L
Fiorentini, C
Di Donato, S
机构：
[1] IRCCS, Ist Nazl Neurol Carlo Besta, Div Biochim & Genet, I-20133 Milan, Italy
[2] IRCCS, Ist Nazl Neurol Carlo Besta, Unit Neuroepidemiol, I-20133 Milan, Italy
[3] Univ Milan, San Paolo Hosp, Div Cardiol, I-20122 Milan, Italy
来源：
NEUROLOGY | 2003年 / 60卷 / 10期
关键词：
D O I：
10.1212/01.WNL.0000055872.50364.FC
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
The authors carried out a 1-year, randomized, placebo-controlled trial of idebenone in 29 patients with Friedreich ataxia. They found significant reductions of interventricular septal thickness and left ventricular mass in the idebenone group vs the placebo group, with no improvement in other heart ultrasound measures or neurologic condition. The absolute cardiac changes were modest, but the findings suggest that larger trials should assess whether idebenone reduces ventricular hypertrophy in patients with Friedreich ataxia.
引用
收藏
页码：1676 / 1679
页数：4
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