Antibiotic-Mediated Modulations of Outer Membrane Vesicles in Enterohemorrhagic Escherichia coli O104:H4 and O157:H7

被引：1
|
作者：
Bauwens, Andreas [1 ]
Kunsmann, Lisa [1 ]
Karch, Helge [1 ,2 ]
Mellmann, Alexander [1 ,2 ]
Bielaszewska, Martina [1 ]
机构：
[1] Univ Munster, Inst Hyg, Munster, Germany
[2] Univ Munster, Interdisciplinary Ctr Clin Res IZKF, Munster, Germany
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2017年 / 61卷 / 09期
关键词：
antibiotics; enterohemorrhagic E. coli; hemolytic uremic syndrome; outer membrane vesicles; Shiga toxins; HEMOLYTIC-UREMIC SYNDROME; SHIGA-TOXIN; PSEUDOMONAS-AERUGINOSA; STRAIN; INFECTION; OUTBREAK; GERMANY; RELEASE; RISK;
D O I：
10.1128/AAC.00937-17
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Ciprofloxacin, meropenem, fosfomycin, and polymyxin B strongly increase production of outer membrane vesicles (OMVs) in Escherichia coli O104:H4 and O157:H7. Ciprofloxacin also upregulates OMV-associated Shiga toxin 2a, the major virulence factor of these pathogens, whereas the other antibiotics increase OMV production without the toxin. These two effects might worsen the clinical outcome of infections caused by Shiga toxin-producing E. coli. Our data support the existing recommendations to avoid antibiotics for treatment of these infections.
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页数：5
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