Formal [4+2] Reaction between 1,3-Diynes and Pyrroles: Gold(I)-Catalyzed Indole Synthesis by Double Hydroarylation

被引：82
|
作者：
Matsuda, Yuka [1 ]
Naoe, Saori [1 ]
Oishi, Shinya [1 ]
Fujii, Nobutaka [1 ]
Ohno, Hiroaki [1 ]
机构：
[1] Kyoto Univ, Grad Sch Pharmaceut Sci, Sakyo Ku, Kyoto 6068501, Japan
来源：
CHEMISTRY-A EUROPEAN JOURNAL | 2015年 / 21卷 / 04期
基金：
日本学术振兴会;
关键词：
carbazoles; cascade reaction; gold catalysis; hydroarylation; indoles; HOMOGENEOUS GOLD CATALYSIS; ONE-POT SYNTHESIS; POLYCYCLIC COMPOUNDS; HYDROAMINATION; CONSTRUCTION; CASCADE; ALKYNES; CYCLIZATION; INHIBITORS; ALKALOIDS;
D O I：
10.1002/chem.201405903
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Indole synthesis by a gold(I)-catalyzed intermolecular formal [4+2] reaction between 1,3-diynes and pyrroles has been developed. This reaction involves the hydroarylation of 1,3-diynes with pyrroles followed by an intramolecular hydroarylation to give the 4,7-disubstituted indoles. This reaction can also be applied to the synthesis of carbazoles when indoles are used as the nucleophiles instead of pyrroles.
引用
收藏
页码：1463 / 1467
页数：5
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