Cerebral blood flow changes during aging process and in cognitive disorders: A review

被引：47
|
作者：
Mokhber, Naghmeh [1 ,2 ]
Shariatzadeh, Aidin [3 ]
Avan, Abolfazl [4 ]
Saber, Hamidreza [5 ]
Babaei, Golnaz Shojaeian [4 ]
Chaimowitz, Gary [6 ]
Azarpazhooh, M. Reza [3 ,7 ]
机构：
[1] Western Univ, Dept Psychiat, London, ON, Canada
[2] Mashhad Univ Med Sci, Dept Psychiat & Neuropsychiat, Mashhad, Razavi Khorasan, Iran
[3] Robarts Res Inst, Stroke Prevent & Atherosclerosis Res Ctr, London, ON, Canada
[4] Mashhad Univ Med Sci, Dept Publ Hlth, Mashhad, Razavi Khorasan, Iran
[5] Wayne State Univ, Sch Med, Dept Neurol, Detroit, MI 48201 USA
[6] McMaster Univ, Dept Psychiat & Behav Neurosci, Hamilton, ON, Canada
[7] Western Univ, Dept Clin Neurol Sci, London, ON, Canada
来源：
NEURORADIOLOGY JOURNAL | 2021年 / 34卷 / 04期
关键词：
Cerebrovascular circulation; neurovascular coupling; functional imaging; cognitive disorders; neuronal loss; aging;
D O I：
10.1177/19714009211002778
中图分类号：
R445 [影像诊断学];
学科分类号：
100207 ;
摘要：
We aimed to summarize the available evidence on cerebral blood flow (CBF) changes in normal aging and common cognitive disorders. We searched PubMed for studies on CBF changes in normal aging and cognitive disorders up to 1 January 2019. We summarized the milestones in the history of CBF assessment and reviewed the current evidence on the association between CBF and cognitive changes in normal aging, vascular cognitive impairment (VCI) and Alzheimer's disease (AD). There is promising evidence regarding the utility of CBF studies in cognition research. Age-related CBF changes could be related to a progressive neuronal loss or diminished activity and synaptic density of neurons in the brain. While a similar cause or outcome theory applies to VCI and AD, it is possible that CBF reduction might precede cognitive decline. Despite the diversity of CBF research findings, its measurement could help early detection of cognitive disorders and also understanding their underlying etiology.
引用
收藏
页码：300 / 307
页数：8
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