Sinulolides A-H, New Cyclopentenone and Butenolide Derivatives from Soft Coral Sinularia sp.

被引：13

作者：

Yang, Bin ^{[1
]}

Wei, Xiaoyi ^{[2
]}

Huang, Jingxia ^{[3
]}

Lin, Xiuping ^{[1
]}

Liu, Juan ^{[1
]}

Liao, Shengrong ^{[1
]}

Wang, Junfeng ^{[1
]}

Zhou, Xuefeng ^{[1
]}

Wang, Lishu ^{[4
]}

Liu, Yonghong ^{[1
]}

机构：

[1] Chinese Acad Sci, South China Sea Inst Oceanol, Res Ctr Marine Microbes, Key Lab Trop Marine Bioresources & Ecol,Guangdong, Guangzhou 510301, Guangdong, Peoples R China

[2] Chinese Acad Sci, Key Lab Plant Resources Conservat & Sustainable U, South China Bot Garden, Guangzhou 510650, Guangdong, Peoples R China

[3] Sun Yat Sen Univ, Zhongshan Ophthalm Ctr, Guangzhou 510060, Guangdong, Peoples R China

[4] Jilin Prov Acad Chinese Med Sci, Changchun 130021, Peoples R China

来源：

MARINE DRUGS | 2014年 / 12卷 / 10期

基金：

中国国家自然科学基金;

关键词：

soft coral; Sinularia sp; sinulolide; NF-kappa B; POLYOXYGENATED STEROIDS; INHIBITORS; GIBBEROSA; CEMBRANOIDS; SESQUITERPENOIDS; DITERPENES; ASSAY;

D O I：

10.3390/md12105316

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Eight new compounds, sinulolides A-H (1-8), along with two known compounds, alpha-methoxy-2,3-dimethyl-butenolide (9) and sinularone D (10), were isolated from the soft coral Sinularia sp. The structures of these compounds were elucidated on the basis of extensive spectroscopic analysis. The absolute configurations were determined on the basis of electronic circular dichroism (ECD) data analysis. Compounds 5 and 10 exhibited moderate effects for the inhibition of NF-kappa B activation.

引用

页码：5316 / 5327

页数：12

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