The Possible Useful Effectiveness of Sinapic Acid on Sepsis-Induced Secondary Organ Damage in Rats

被引：5
|
作者：
Tanyeli, Ayhan [1 ]
Akdemir, Fazile Nur Ekinci [2 ]
Eraslan, Ersen [3 ]
Guler, Mustafa Can [1 ]
Sebin, Saime Ozbek [1 ]
Comakli, Selim [4 ]
Gulcin, Ilhami [5 ]
机构：
[1] Ataturk Univ, Fac Med, Dept Physiol, Erzurum, Turkey
[2] Ibrahim Cecen Univ Agri, Fac Hlth Sci, Dept Nutr & Dietet, Agri, Turkey
[3] Bozok Univ, Fac Med, Dept Physiol, Yozgat, Turkey
[4] Ataturk Univ, Fac Vet, Dept Patol, Erzurum, Turkey
[5] Ataturk Univ, Fac Sci, Dept Chem, Erzurum, Turkey
来源：
CLINICAL AND EXPERIMENTAL HEALTH SCIENCES | 2022年 / 12卷 / 01期
关键词：
Cecal ligation puncture; sinapic acid; lung; kidney; rat; CECAL LIGATION; ANTIOXIDANT ACTIVITY; OXIDATIVE STRESS; INDUCED NEPHROTOXICITY; FREE-RADICALS; LUNG INJURY; IN-VITRO; INFLAMMATION; MODEL; APOPTOSIS;
D O I：
10.33808/clinexphealthsci.864015
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Objectives: In this study, we investigated the possible useful effectiveness of Sinapic acid on rat kidney and lung tissues in an experimental cecal ligation puncture (CLP) model. Methods: CLP model was created for the rats in the CLP group. 20 mg/kg of Sinapic acid was given in the CLP-Sinapic acid group. At the end of the experiment, lung and kidney tissues were collected and biochemical analyzes were evaluated. Results: For the lung and kidney tissue samples; antioxidant levels decreased, and oxidant levels increased in the CLP group. When the immunohistochemical parameters were evaluated, IL-1 beta, caspase-3, and TNF-alpha immunopositivity were severe levels in CLP group. But immunopositivity of these parameters have been observed as attenuated in CLP-Sinapic acid group compared to CLP group. Conclusion: The results of our study showed that Sinapic acid has useful effectiveness on the sepsis model caused by CLP in the lung and kidney tissues.
引用
收藏
页码：134 / 140
页数：7
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