Novel site-specific DNA endonucleases

被引：27

作者：

Aggarwal, AK ^{[1
]}

Wah, DA ^{[1
]}

机构：

[1] CUNY Mt Sinai Sch Med, Dept Physiol & Biophys, Struct Biol Program, New York, NY 10029 USA

来源：

CURRENT OPINION IN STRUCTURAL BIOLOGY | 1998年 / 8卷 / 01期

关键词：

D O I：

10.1016/S0959-440X(98)80005-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Site-specific hydrolysis of DNA is common to many biological processes. Three new structures, FokI, I-Crel and PI-SceI, were reported in the past year, providing the first view of type IIs endonucleases and homing endonucleases. Together, they reveal an extraordinary set of new mechanisms by which endonucleases target the hydrolysis of specific DNA sequences.

引用

页码：19 / 25

页数：7

共 40 条

[1] STRUCTURE AND FUNCTION OF RESTRICTION ENDONUCLEASES [J].

AGGARWAL, AK .

CURRENT OPINION IN STRUCTURAL BIOLOGY, 1995, 5 (01) :11-19

[2] RESTRICTION ENDONUCLEASES AND MODIFICATION METHYLASES [J].

ANDERSON, JE .

CURRENT OPINION IN STRUCTURAL BIOLOGY, 1993, 3 (01) :24-30

[3] Homing endonucleases: keeping the house in order [J].

Belfort, M ;

Roberts, RJ .

NUCLEIC ACIDS RESEARCH, 1997, 25 (17) :3379-3388

[4] SELECTION OF A REMOTE CLEAVAGE SITE BY I-TEVI, THE TD INTRON-ENCODED ENDONUCLEASE [J].

BRYK, M ;

BELISLE, M ;

MUELLER, JE ;

BELFORT, M .

JOURNAL OF MOLECULAR BIOLOGY, 1995, 247 (02) :197-210

[5] MODE OF INTERACTION OF THE ZINC FINGER PROTEIN TFIIIA WITH A 5S RNA GENE OF XENOPUS [J].

CHURCHILL, MEA ;

TULLIUS, TD ;

KLUG, A .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (14) :5528-5532

[6] DEFINITION OF THE BINDING-SITES OF INDIVIDUAL ZINC FINGERS IN THE TRANSCRIPTION FACTOR-IIIA-5S RNA GENE-COMPLEX [J].

CLEMENS, KR ;

LIAO, XB ;

WOLF, V ;

WRIGHT, PE ;

GOTTESFELD, JM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (22) :10822-10826

[7] PROTEIN SPLICING - SELF-SPLICING OF GENETICALLY MOBILE ELEMENTS AT THE PROTEIN LEVEL [J].

COOPER, AA ;

STEVENS, TH .

TRENDS IN BIOCHEMICAL SCIENCES, 1995, 20 (09) :351-356

[8] Two-domain structure of the td intron-encoded endonuclease I-TevI correlates with the two-domain configuration of the homing site [J].

Derbyshire, V ;

Kowalski, JC ;

Dansereau, JT ;

Hauer, CR ;

Belfort, M .

JOURNAL OF MOLECULAR BIOLOGY, 1997, 265 (05) :494-506

[9] Crystal structure of PI-Scel, a homing endonuclease with protein splicing activity [J].

Duan, XQ ;

Gimble, FS ;

Quiocho, FA .

CELL, 1997, 89 (04) :555-564

[10] CRYSTAL-STRUCTURE OF DCOH, A BIFUNCTIONAL, PROTEIN-BINDING TRANSCRIPTIONAL COACTIVATOR [J].

ENDRIZZI, JA ;

CRONK, JD ;

WANG, WD ;

CRABTREE, GR ;

ALBER, T .

SCIENCE, 1995, 268 (5210) :556-559

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