STRUCTURE AND FUNCTION OF RESTRICTION ENDONUCLEASES

被引：171
作者：
AGGARWAL, AK
机构：
[1] AK Aggarwal, Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032
来源：
CURRENT OPINION IN STRUCTURAL BIOLOGY | 1995年 / 5卷 / 01期
关键词：
D O I：
10.1016/0959-440X(95)80004-K
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Structures of two restriction endonucleases, BamHI and PvuII, were reported in the past year. This doubles the number of restriction endonuclease structures now known from two to four, and enables a comparative analysis of their structures and modes of DNA recognition. Despite a lack oi sequence homology between the enzymes, BamHI turns out to resemble EcoRI, and PvuII turns out to resemble EcoRV. The active-site regions are structurally similar in all four enzymes, but their mechanisms of cleavage may differ.
引用
收藏
页码：11 / 19
页数：9
相关论文
共 28 条
[1]   RESTRICTION ENDONUCLEASES AND MODIFICATION METHYLASES [J].
ANDERSON, JE .
CURRENT OPINION IN STRUCTURAL BIOLOGY, 1993, 3 (01) :24-30
[2]   CRYSTAL-STRUCTURE OF PVUII ENDONUCLEASE REVEALS EXTENSIVE STRUCTURAL HOMOLOGIES TO ECORV [J].
ATHANASIADIS, A ;
VLASSI, M ;
KOTSIFAKI, D ;
TUCKER, PA ;
WILSON, KS ;
KOKKINIDIS, M .
NATURE STRUCTURAL BIOLOGY, 1994, 1 (07) :469-475
[3]   STRUCTURAL BASIS FOR THE 3'-5' EXONUCLEASE ACTIVITY OF ESCHERICHIA-COLI DNA-POLYMERASE-I - A 2 METAL-ION MECHANISM [J].
BEESE, LS ;
STEITZ, TA .
EMBO JOURNAL, 1991, 10 (01) :25-33
[4]   STRUCTURE OF PVUII ENDONUCLEASE WITH COGNATE DNA [J].
CHENG, XD ;
BALENDIRAN, K ;
SCHILDKRAUT, I ;
ANDERSON, JE .
EMBO JOURNAL, 1994, 13 (17) :3927-3935
[5]  
CONNOLLY BA, 1984, J BIOL CHEM, V259, P760
[6]   STEREOCHEMICAL OUTCOME OF THE HYDROLYSIS REACTION CATALYZED BY THE ECORV RESTRICTION ENDONUCLEASE [J].
GRASBY, JA ;
CONNOLLY, BA .
BIOCHEMISTRY, 1992, 31 (34) :7855-7861
[7]   DNA RECOGNITION BY PROTEINS WITH THE HELIX-TURN-HELIX MOTIF [J].
HARRISON, SC ;
AGGARWAL, AK .
ANNUAL REVIEW OF BIOCHEMISTRY, 1990, 59 :933-969
[8]   SUBSTRATE-ASSISTED CATALYSIS IN THE CLEAVAGE OF DNA BY THE ECORI AND ECORV RESTRICTION ENZYMES [J].
JELTSCH, A ;
ALVES, J ;
WOLFES, H ;
MAASS, G ;
PINGOUD, A .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (18) :8499-8503
[9]   REFINEMENT OF ECO RI ENDONUCLEASE CRYSTAL-STRUCTURE - A REVISED PROTEIN CHAIN TRACING [J].
KIM, YC ;
GRABLE, JC ;
LOVE, R ;
GREENE, PJ ;
ROSENBERG, JM .
SCIENCE, 1990, 249 (4974) :1307-1309
[10]   MOLSCRIPT - A PROGRAM TO PRODUCE BOTH DETAILED AND SCHEMATIC PLOTS OF PROTEIN STRUCTURES [J].
KRAULIS, PJ .
JOURNAL OF APPLIED CRYSTALLOGRAPHY, 1991, 24 :946-950
123