Effects of MEDI0382, a glucagon-like peptide 1/glucagon receptor dual agonist, on pancreatic and incretin hormones

被引：0
|
作者：
Jermutus, L. [1 ]
Tsai, L. -F. [2 ]
Robertson, D. [1 ]
Petrone, M. [1 ]
Rondinone, C. [2 ]
Boaz, H. [2 ]
Ambery, P. [1 ]
Parker, V. [1 ]
机构：
[1] MedImmune, Cambridge, England
[2] MedImmune, Gaithersburg, MD USA
来源：
DIABETOLOGIA | 2018年 / 61卷
关键词：
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
778
引用
收藏
页码：S382 / S382
页数：1
相关论文
共 50 条
  • [21] A Novel Glucagon-Like Peptide 1/Glucagon Receptor Dual Agonist Improves Steatohepatitis and Liver Regeneration in Mice
    Valdecantos, M. Pilar
    Pardo, Virginia
    Ruiz, Laura
    Castro-Sanchez, Luis
    Lanzon, Borja
    Fernandez-Millan, Elisa
    Garcia-Monzon, Carmelo
    Arroba, Ana I.
    Gonzalez-Rodriguez, Agueda
    Escriva, Fernando
    Alvarez, Carmen
    Ruperez, Francisco J.
    Barbas, Coral
    Konkar, Anish
    Naylor, Jacqui
    Hornigold, David
    Dos Santos, Ana
    Bednarek, Maria
    Grimsby, Joseph
    Rondinone, Cristina M.
    Valverde, Angela M.
    HEPATOLOGY, 2017, 65 (03) : 950 - 968
  • [22] PANCREATIC SAFETY IN STUDIES OF THE GLUCAGON-LIKE PEPTIDE-1 RECEPTOR AGONIST ALBIGLUTIDE
    Al-Kawas, Firas
    Anderson, Michelle Ann
    Enns, Robert
    Wilson, Timothy H.
    Johnson, Susan
    Mallory, Jason M.
    ENDOCRINE PRACTICE, 2019, 25 (07) : 698 - 716
  • [23] Effects of MEDI0382, an Oxyntomodulin-Like Peptide with Targeted GLP-1/Glucagon Receptor Activity, on Amino Acids, Ketones, and Free Fatty Acids
    Parker, Victoria E.
    Robertson, Darren
    Wang, Tao
    Hornigold, David C.
    Posch, Maximilian G.
    Plum-Moerschel, Leona
    Meier, Juris J.
    Schlichthaar, Heike
    Klaus, Beate M.
    Jermutus, Lutz
    Ambery, Philip
    Hirshberg, Boaz
    DIABETES, 2019, 68
  • [24] MEDI0382, a GLP/Glucagon Receptor Dual Agonist, Significantly Reduces Hepatic Fat Content in Subjects with Type 2 Diabetes Mellitus
    Jain, Meena
    Tsai, Lan-Feng
    Robertson, Darren
    Hirshberg, Boaz
    Hockings, Paul
    Johansson, Lars
    Ambery, Philip
    DIABETES, 2018, 67
  • [25] MEDI0382, a GLP-1/Glucagon Receptor Dual Agonist, in Patients with Type 2 Diabetes-A Multiple-Ascending-Dose Study
    Robertson, Darren
    Stumvoll, Michael W.
    Posch, Maximilian G.
    Heise, Tim
    Plum-Moerschel, Leona
    Klein, Gernot
    Tsai, Lan-Feng
    Petrone, Marcella
    Hirshberg, Boaz
    Rondinone, Cristina
    Parker, Victoria E.
    Jermutus, Lutz
    Ambery, Philip
    DIABETES, 2018, 67
  • [26] The effects of Fc fusion protein glucagon-like peptide-1 and glucagon dual receptor agonist with different receptor selectivity in vivo studies
    Jiang, Peng
    Zeng, Ying
    Yang, Wen
    Li, Lijia
    Zhou, Linjun
    Li, Yong
    Gu, Baohua
    Li, Xiaoping
    Li, Jing
    Li, Wenjia
    Guo, Linfeng
    BIOMEDICINE & PHARMACOTHERAPY, 2024, 174
  • [27] MEDI0382, a dual GLP-1/glucagon receptor agonist, exerts beneficial effects on mitochondrial content and function in primary hepatocytes from lean and NASH mice
    Beaton, Michelle L.
    Grimsby, Joseph
    Rhodes, Christopher
    Jermutus, Lutz
    Konkar, Anish
    Trevaskis, James
    HEPATOLOGY, 2016, 64 : 787A - 787A
  • [28] Acute Metabolic Effects of MEDI0382, a GLP-1/Glucagon Dual Agonist, in Wild Type and GLP-1 Receptor Knockout (GLP-1RKO) Mice
    Will, Sarah E.
    Naylor, Jacqueline
    Rossi, Alessandra
    Hornigold, David
    Oldham, Stephanie
    Trevaskis, James
    Konkar, Anish
    DIABETES, 2016, 65 : A35 - A35
  • [29] Thermo-Responsive self-assembly of a dual glucagon-like peptide and glucagon receptor agonist
    Kinna, Sonja
    Ouberai, Myriam M.
    Sonzini, Silvia
    Dos Santos, Ana L. Gomes
    Welland, Mark E.
    INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2021, 604
  • [30] MEDI0382, a dual GLP-1 glucagon receptor agonist, promotes rapid glucose control and significant weight loss in patients with type 2 diabetes
    Parker, V.
    Ambery, P.
    Robertson, D.
    Posch, M.
    Plum-Moerschel, L.
    Wang, T.
    Petrone, M.
    Heise, T.
    Meier, J.
    Hirshberg, B.
    DIABETOLOGIA, 2018, 61 : S84 - S84
12345