Liquid membrane/polyaniline film coated glassy carbon sensor for highly sensitive and selective determination of fluvoxamine in pharmaceutical and biological samples

A novel and very sensitive potentiometric sensor with excellent electrochemical properties was fabricated for the determination of fluvoxamine. The sensor is based on the use of the PVC-membrane containing ion-association complex of fluvoxamine with reinecke salt coated on the glassy carbon electrode which was modified with polyaniline as a conductive polymeric film. The proposed sensor exhibits a Nernstian slope of 58.9 mV per decade for fluvoxamine over a wide concentration range of 1.8 x 10(-7)-1.3 x 10(-3) M, with a low detection limit of 7.8 x 10(-8) M. The sensor has a fast response time, excellent reproducibility and long life time. It can be used within the pH range of 4.0-7.5 in a long time period. The sensor possesses a high selectivity toward a large variety of inorganic and organic co-existing species. The effect of temperature on the sensor potential response was studied and the isothermal coefficient of the sensor was calculated. The sensor has a good thermal stability within the studied temperature range. The developed sensor was used as an indicator electrode in potentiometric titration of fluvoxamine with sodium tetraphenylborate. The sensor was successfully applied in the determination of fluvoxamine in pharmaceutical solution, blood serum and urine samples. (C) 2017 Elsevier B.V. All rights reserved.