Titanium-mediated synthesis of bicyclic cyclopropylamines from unsaturated nitriles

被引：37
|
作者：
Laroche, C [1 ]
Bertus, P [1 ]
Szymoniak, J [1 ]
机构：
[1] Univ Reims, CNRS, UMR 6519 React Select & Applicat, UFR Sci, F-51687 Reims 2, France
来源：
TETRAHEDRON LETTERS | 2003年 / 44卷 / 12期
关键词：
bicyclic compounds; cyclizations; cyclopropanes; nitriles; titanium;
D O I：
10.1016/S0040-4039(03)00325-3
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Here we report an easy synthesis of bicyclic primary cyclopropylamines directly from unsaturated nitriles. The described reaction involves Ti(II)-mediated intramolecular coupling of alkene and nitrile moieties. (C) 2003 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：2485 / 2487
页数：3
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