The essential function of HP1β: a case of the tail wagging the dog?

被引：21
|
作者：
Billur, Mustafa [1 ]
Bartunik, Hans D. [2 ]
Singh, Prim B. [1 ]
机构：
[1] Forschungszentrum Borstel, Dept Immunol & Cell Biol, Div Immunoepigenet, D-23845 Borstel, Germany
[2] Max Planck Unit Struct Mol Biol, MPG ASMB, Deutsch Elektronsynchrotron DESY, D-22603 Hamburg, Germany
来源：
TRENDS IN BIOCHEMICAL SCIENCES | 2010年 / 35卷 / 02期
关键词：
POSITION-EFFECT VARIEGATION; HETEROCHROMATIN PROTEIN-1 HP1; HISTONE H3; MAMMALIAN-CELLS; CHROME DOMAIN; PERICENTRIC HETEROCHROMATIN; SHADOW DOMAIN; DNA-DAMAGE; LYSINE; 9; DROSOPHILA;
D O I：
10.1016/j.tibs.2009.09.003
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A large body of work in various organisms has shown that the presence of HP1 structural proteins and methylated lysine 9 of histone H3 (H3K9me) represent the characteristic hallmarks of heterochromatin. We propose that a more critical assessment of the physiological importance of the H3K9me-HP1 interaction is warranted in light of recent studies on the mammalian HP1 beta protein. Based on this new research, we conclude that the essential function of HP1 beta (and perhaps that of its orthologues in other species) lies outside the canonical heterochromatic H3K9me-HP1 interaction. We suggest instead that binding of a small fraction of HP1 beta to the H3 histone fold performs a critical role in heterochromatin function and organismal survival.
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页码：115 / 123
页数：9
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