Cannabidiol: State of the art and new challenges for therapeutic applications

被引：398
|
作者：
Pisanti, Simona [1 ]
Malfitano, Anna Maria [1 ]
Ciaglia, Elena [1 ]
Lamberti, Anna [1 ]
Ranieri, Roberta [1 ]
Cuomo, Gaia [1 ]
Abate, Mario [1 ]
Faggiana, Giorgio [1 ]
Proto, Maria Chiara [2 ]
Fiore, Donatella [2 ]
Laezza, Chiara [3 ]
Bifulco, Maurizio [1 ,4 ]
机构：
[1] Univ Salerno, Dept Med Surg & Dent, Scuola Med Salernitana, Via Salvatore Allende, Baronissi, SA, Italy
[2] Univ Salerno, Dept Pharm, Fisciano, SA, Italy
[3] IEOS CNR Naples, Naples, Italy
[4] Fdn Idis Citta Sci, Corporea, Naples, Italy
来源：
PHARMACOLOGY & THERAPEUTICS | 2017年 / 175卷
关键词：
Cannabis; Cannabidiol; Endocannabinoid system; Neurological diseases; Cancer; CANNABINOID CB1 RECEPTOR; LUNG-CANCER CELLS; EQUILIBRATIVE NUCLEOSIDE TRANSPORTER; NON-PSYCHOACTIVE COMPONENT; DEPENDENT VASCULAR ACTIONS; CASPASE-MEDIATED CLEAVAGE; NF-KAPPA-B; IN-VITRO; PARKINSONS-DISEASE; MULTIPLE-SCLEROSIS;
D O I：
10.1016/j.pharmthera.2017.02.041
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Over the past years, several lines of evidence support a therapeutic potential of Cannabis derivatives and in particular phytocannabinoids. Delta(9)-THC and cannabidiol (CBD) are the most abundant phytocannabinoids in Cannabis plants and therapeutic application for both compounds have been suggested. However, CBD is recently emerging as a therapeutic agent in numerous pathological conditions since devoid of the psychoactive side effects exhibited instead by Delta(9)-THC. In this review, we highlight the pharmacological activities of CBD, its cannabinoid receptor-dependent and -independent action, its biological effects focusing on immunomodulation, angiogenetic properties, and modulation of neuronal and cardiovascular function. Furthermore, the therapeutic potential of cannabidiol is also highlighted, in particular in nuerological diseases and cancer. (C) 2017 Published by Elsevier Inc.
引用
收藏
页码：133 / 150
页数：18
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