N-methylpyrrolidine as an effective organocatalyst for the regioselective synthesis of 3-hydroxy-3,5/6-di-aryl-1H-imidazo[1,2-a]imidazol-2(3H)-ones

被引：3

作者：

Habashi, Bayram Parsa ^{[1
]}

Marjani, Ahmad Poursattar ^{[1
]}

机构：

[1] Urmia Univ, Fac Chem, Dept Organ Chem, Orumiyeh, Iran

来源：

RESEARCH ON CHEMICAL INTERMEDIATES | 2022年 / 48卷 / 06期

关键词：

Aryl glyoxal monohydrates (AG hydrates); Catalyst; 1H-imidazo[1,2-a] imidazol-2(3H)-ones; Guanidine hydrochloride; N-methylpyrrolidine; ONE-POT; EFFICIENT;

D O I：

10.1007/s11164-022-04717-6

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

N-Methylpyrrolidine catalyzed, concise and attractive synthesis of a new class of 3-hydroxy-3,5/6-di-aryl-1H-imidazo[1,2-a]imidazol-2(3H)-ones was attained with impressive yields, in the presence of EtOH as a solvent, by means of a convenient and elegant condensation reaction between different aryl glyoxal monohydrates and guanidine hydrochloride under reflux conditions. Some specific merits of the current procedure, including encompasses low operating cost, availability of the starting substrates, reasonable reaction times, high reaction yield, operational simplicity, cleaner reaction profile, no harmful by-products, and the isolated product is in pure form. Structures of all the freshly synthesized products have been deduced by their FT-IR, H-1-NMR, C-13- NMR, Mass spectrometry data and microanalysis. [GRAPHICS] .

引用

页码：2325 / 2336

页数：12

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