Antibacterial and anti-inflammatory agents that target endotoxin

被引：97
|
作者：
Wyckoff, TJO [1 ]
Raetz, CRH [1 ]
Jackman, JE [1 ]
机构：
[1] Duke Univ, Dept Biochem, Med Ctr, Durham, NC 27710 USA
来源：
TRENDS IN MICROBIOLOGY | 1998年 / 6卷 / 04期
关键词：
D O I：
10.1016/S0966-842X(98)01230-X
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Antibiotic-resistant bacterial infections are a major clinical problem. Lipid A, the active part of lipopolysaccharide endotoxins in. Gram-negative bacteria, is an intriguing target for new antibacterial and anti-inflammatory agents. Inhibition of lipid A biosynthesis kills most Gram-negative bacteria, increases bacterial permeability to antibiotics and decreases endotoxin production.
引用
收藏
页码：154 / 159
页数：6
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