PKM2 released by neutrophils at wound site facilitates early wound healing by promoting angiogenesis

被引：43
|
作者：
Zhang, Yinwei [1 ]
Li, Liangwei [1 ]
Liu, Yuan [1 ]
Liu, Zhi-Ren [1 ]
机构：
[1] Georgia State Univ, Dept Biol, Univ Plaza, Atlanta, GA 30303 USA
来源：
WOUND REPAIR AND REGENERATION | 2016年 / 24卷 / 02期
关键词：
PYRUVATE-KINASE M2; TUMOR M2-PYRUVATE KINASE; CATHEPSIN-G; SECRETORY VESICLES; LYSOSOMAL ELASTASE; MARKER; M2-PK; PROTEIN; GROWTH; REPAIR;
D O I：
10.1111/wrr.12411
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Neutrophils infiltration/activation following wound induction marks the early inflammatory response in wound repair. However, the role of the infiltrated/activated neutrophils in tissue regeneration/proliferation during wound repair is not well understood. Here, we report that infiltrated/activated neutrophils at wound site release pyruvate kinase M2 (PKM2) by its secretive mechanisms during early stages of wound repair. The released extracellular PKM2 facilitates early wound healing by promoting angiogenesis at wound site. Our studies reveal a new and important molecular linker between the early inflammatory response and proliferation phase in tissue repair process.
引用
收藏
页码：328 / 336
页数：9
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